Collomp K, Candau R, Collomp R, Carra J, Lasne F, Préfaut C, De Ceaurriz J
Laboratoire National de Dépistage du Dopage, Chatenay-Malabry, France.
Int J Sports Med. 2000 Oct;21(7):480-4. doi: 10.1055/s-2000-7422.
To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80-85% VO2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.
为评估急性口服沙丁胺醇对次极量运动期间运动表现和代谢的最终影响，九名健康志愿者按照双盲随机方案，在接受安慰剂（Pla）或沙丁胺醇（Sal，6毫克）治疗后，以相当于80 - 85%最大摄氧量（VO2max）的功率完成了两次骑行试验。在静息状态和运动期间（运动5分钟、10分钟、15分钟直至力竭）采集血样，用于测量C肽、游离脂肪酸（FFA）、乳酸和血糖。与安慰剂试验相比，沙丁胺醇试验中的骑行表现显著改善（p < 0.05）。摄入沙丁胺醇后，静息时的C肽、乳酸、游离脂肪酸和血糖值升高，而运动期间及运动结束时的运动乳酸和游离脂肪酸浓度更高（p < 0.05）。这些结果表明，急性摄入沙丁胺醇可能通过增强有氧和无氧代谢对能量产生的总体贡献，改善了次极量运动期间的运动表现。
