Pancreatic tumors show high levels of hypoxia.

作者信息

Koong A C, Mehta V K, Le Q T, Fisher G A, Terris D J, Brown J M, Bastidas A J, Vierra M

机构信息

Department Radiation Oncology, Stanford University Medical Center, Stanford, CA 94305, USA.

出版信息

Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):919-22. doi: 10.1016/s0360-3016(00)00803-8.

PURPOSE

Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.

METHODS AND MATERIALS

Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.

RESULTS

All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.

CONCLUSION

Tumor hypoxia exists within pancreatic cancers.