在产肠毒素大肠杆菌中丝裂霉素C诱导热不稳定肠毒素的合成。
Induction of heat-labile enterotoxin synthesis in enterotoxigenic Escherichia coli mitomycin C.
作者信息
Isaacson R E, Moon H W
出版信息
Infect Immun. 1975 Dec;12(6):1271-5. doi: 10.1128/iai.12.6.1271-1275.1975.
Abstract
Introduction of heat-labile toxin (LT) synthesis in enterotocigenic strains of Escherichia coli by mitomycin C (MTC) was demonstrated. Six enteropathogenic strains which produce LT were inducible, exhibiting an 896-fold increase in LT when compared to ininduced cultures. On the other hand, four nonenteropathogens and three other pathogens which produce only the heat-stable toxin were not induced to produce LT. Gel filtration chromatography, antibody neutration, and heat lability studies suggest that the toxin synthesized in the presence of MTC is the same as the toxin synthesized in the absence of MTC.
摘要
已证实，丝裂霉素C（MTC）可诱导产肠毒素大肠杆菌的产毒株合成不耐热毒素（LT）。6株产LT的肠道致病菌株具有诱导性，与未诱导培养物相比，LT产量增加了896倍。另一方面，4株非致病菌和3株仅产耐热毒素的其他病原菌未被诱导产生LT。凝胶过滤色谱法、抗体中和法和热稳定性研究表明，在MTC存在下合成的毒素与在MTC不存在时合成的毒素相同。
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