丝裂霉素C可刺激志贺氏菌属产生一种毒素，该毒素会导致中国仓鼠卵巢细胞发生形态变化。
Mitomycin C stimulates production of a toxin in Shigella species that causes morphological changes in Chinese hamster ovary cells.
作者信息
Takeda Y, Okamoto K, Miwatani T
出版信息
Infect Immun. 1979 Jan;23(1):178-80. doi: 10.1128/iai.23.1.178-180.1979.
Abstract
Shigella dysenteriae produced a toxin that caused morphological changes in Chinese hamster ovary cells which was different from the neurotoxin (Y. Takeda, K. Okamoto, and T. Miwatani, Infect. Immun. 18:546--548, 1977). It was found that the toxin was produced not only by S. dysenteriae but also by S. flexneri, S. boydii, and S. sonnei. The production of the toxin was stimulated by the addition of 1 microgram of mitomycin C per ml to the culture in the early logarithmic growth phase.
摘要
痢疾志贺菌产生一种毒素，该毒素可引起中国仓鼠卵巢细胞发生形态变化，这种变化不同于神经毒素（武田洋、冈本健、三渡谷敏，《感染与免疫》18:546 - 548，1977年）。研究发现，不仅痢疾志贺菌能产生这种毒素，福氏志贺菌、鲍氏志贺菌和宋内志贺菌也能产生。在对数生长早期向培养物中每毫升添加1微克丝裂霉素C可刺激毒素的产生。
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