Wilcox M H, Fawley W N
Lancet. 2000 Oct 14;356(9238):1324. doi: 10.1016/S0140-6736(00)02819-1.
Evidence is lacking on how best to decontaminate the hospital environment of Clostridium difficile. We compared sporulation levels in the UK epidemic C. difficile strain (P24), another clinical isolate (B31), and an environmental strain (E4) cultured in faecal emulsion containing subinhibitory concentrations of one of five hospital cleaning agents. The epidemic strain produced significantly more spores than the non-prevalent strains, and sporulation was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C. difficile spores in the hospital environment.
关于如何最佳地对艰难梭菌进行医院环境去污的证据不足。我们比较了在含有五种医院清洁制剂之一的亚抑制浓度的粪便乳剂中培养的英国流行的艰难梭菌菌株（P24）、另一种临床分离株（B31）和一种环境菌株（E4）的孢子形成水平。流行菌株产生的孢子明显多于非流行菌株，并且当该菌株在暴露于非氯基清洁制剂的粪便中培养时，孢子形成会进一步增强。清洁制剂的选择对艰难梭菌孢子在医院环境中的持久性可能有重大影响。
