膜脂对醇类的适应性
Adaptation of membrane lipids to alcohols.
作者信息
Ingram L O
出版信息
J Bacteriol. 1976 Feb;125(2):670-8. doi: 10.1128/jb.125.2.670-678.1976.
Abstract
The effects of alcohols of different chain lengths on the fatty acid composition of Escherichia coli K-12 have been examined. My results indicate that these cells radically change their fatty acid composition when grown in the presence of alcohols. These changes represent an adaptive membrane alteration compensating for the direct physicochemical interaction of alcohols with the membrane. Similar adaptive responses of membrane lipids are proposed as a possible biochemical basis for tolerance to alcohol and related drugs.
摘要
已研究了不同链长的醇类对大肠杆菌K-12脂肪酸组成的影响。我的结果表明，这些细胞在醇类存在的情况下生长时，其脂肪酸组成会发生根本性变化。这些变化代表了一种适应性膜改变，以补偿醇类与膜的直接物理化学相互作用。膜脂的类似适应性反应被认为是对酒精及相关药物耐受性的一种可能的生化基础。
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