Sullivan K H, Hegeman G D, Cordes E H
J Bacteriol. 1979 Apr;138(1):133-8. doi: 10.1128/jb.138.1.133-138.1979.
The addition of normal alcohols in the series n-butanol to n-octanol to cultures of Escherichia coli ML308 grown on defined or lipid-free medium (at 17, 27, and 37 degrees C) caused an alteration in the fatty acid composition of this organism: the ratio of saturated to unsaturated fatty acids increased. Changes in the relative quantities of individual fatty acid species elicited by increasing concentrations of these alcohols were as follows: (i) myristic acid remained constant: (ii) palmitic acid increased; and (iii) the combined amount of palmitoleic plus cis-methylene hexadecanoic acids changed in a way which was reflected inversely by changes in the amount of cis-vaccenic acid. Comparable changes were not observed when cells were grown in the presence of n-nonanol and n-decanol in the concentration range tested. The changes observed upon addition of normal alcohols (n-butanol to n-octanol) paralleled, in part, the alterations in fatty acid composition observed when growth temperature was increased.
在限定培养基或无脂质培养基上生长的大肠杆菌ML308培养物中添加正丁醇至正辛醇系列的正常醇类（在17、27和37摄氏度下），导致该生物体脂肪酸组成发生变化：饱和脂肪酸与不饱和脂肪酸的比例增加。随着这些醇类浓度的增加，引发的各个脂肪酸种类相对含量的变化如下：（i）肉豆蔻酸保持不变；（ii）棕榈酸增加；（iii）棕榈油酸和顺式亚甲基十六烷酸的总量变化与顺式vaccenic酸含量变化呈相反反映。在测试浓度范围内，当细胞在正壬醇和正癸醇存在下生长时，未观察到类似变化。添加正常醇类（正丁醇至正辛醇）时观察到的变化部分与生长温度升高时观察到的脂肪酸组成变化相似。
