Parazzini F, Di Cintio E, Chiantera V, Guaschino S
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy.
Eur J Obstet Gynecol Reprod Biol. 2000 Dec;93(2):141-5. doi: 10.1016/s0301-2115(00)00289-x.
We have analyzed the differences in the epidemiological characteristics of women with different Candida low female genital tract infection.
Eligible for the study were 4228 women aged 18-70 years with symptomatic low gynecological tract infection and clinical findings suggestive for Candida infection consecutively attending during the study period first level outpatients gynecological services in Italy. CHROMagar Candida method was used to identify albicans and non-albicans species and among non-albicans ones Candida glabrata, tropicalis and krusei.
Out of the 4228 women who entered the study, Candida infection was confirmed by CHROMagar test in 3351 cases (79.3%): Candida albicans was identified in 1431 cases (43%) and non-albicans in 1920. Among the 1920 women with non-albicans infection, Candida glabrata was identified in 1207 women, Candida krusei in 290, Candida tropicalis in 404 (in 19 cases other species or non-specified species were involved). Candida albicans infection was more frequently reported than non-albicans ones in diabetic women (Odds Ratio, OR=1.7, 95%, Confidence Interval, CI 1.1-2.7). Current oral contraceptive users tended more frequently to be infected with Candida albicans than non-albicans, however the estimated OR was only slightly above unity and of borderline statistical significance (OR 1.3, 9.5%, CI 1.1-1.5). Women reporting previous treatment with topic antimicotic reported more frequently non-albicans infection, than Candida albicans ones. However the association was limited and of borderline statistical significance (OR albicans vs. non albicans 0.7, 95% CI 0.5-1.0). Albicans infection was more frequently identified in women whose partner reported symptomatology for Candida infection (OR 1.7, 95% C.I. 1.4-2.0).
This study shows that in this Italian population with symptomatic Candida infection of low female genital tract, there are some differences in the epidemiological characteristics of women with albicans and non-albicans infection.
我们分析了不同念珠菌所致女性下生殖道感染的流行病学特征差异。
本研究纳入了4228名年龄在18至70岁之间、有症状的下生殖道感染且临床检查结果提示念珠菌感染的女性，她们在研究期间连续就诊于意大利一级门诊妇科。采用科玛嘉念珠菌显色培养基法鉴定白色念珠菌和非白色念珠菌，在非白色念珠菌中鉴定光滑念珠菌、热带念珠菌和克柔念珠菌。
在参与研究的4228名女性中，科玛嘉试验确诊念珠菌感染3351例（79.3%）：白色念珠菌1431例（43%），非白色念珠菌1920例。在1920例非白色念珠菌感染的女性中，光滑念珠菌1207例，克柔念珠菌290例，热带念珠菌404例（19例涉及其他菌种或未明确的菌种）。糖尿病女性中白色念珠菌感染的报告频率高于非白色念珠菌感染（优势比，OR = 1.7，95%置信区间，CI 1.1 - 2.7）。当前口服避孕药使用者感染白色念珠菌的频率往往高于非白色念珠菌，然而估计的OR仅略高于1，具有临界统计学意义（OR 1.3，95% CI 1.1 - 1.5）。报告曾接受局部抗真菌治疗的女性，非白色念珠菌感染的报告频率高于白色念珠菌感染。然而这种关联有限，具有临界统计学意义（白色念珠菌与非白色念珠菌的OR为0.7，95% CI 0.5 - 1.0）。伴侣有念珠菌感染症状的女性中白色念珠菌感染更为常见（OR 1.7，95% C.I. 1.4 - 2.0）。
本研究表明，在意大利这个有症状性念珠菌感染的女性下生殖道人群中，白色念珠菌和非白色念珠菌感染的女性在流行病学特征上存在一些差异。
