Haslam N, Mayberry J F, Hawthorne A B, Newcombe R G, Holmes G K, Probert C S
Gloucestershire Royal Hospital, Great Western Road, Gloucester, UK.
Gut. 2000 Dec;47(6):801-3. doi: 10.1136/gut.47.6.801.
The rise in the incidence of Crohn's disease (CD) suggests the role of an environmental factor in the development of the disease in susceptible individuals. Perinatal exposure to infection has been proposed as such an environmental factor.
To investigate the influence of birth date on the development of CD in later life.
Four registers of patients with CD, diagnosed from 1972 to 1989, were combined, and data from 1624 patients were examined. The birth dates of CD patients were compared with national birth figures for three decades (1941-50, 1951-60, and 1961-70) to avoid temporal changes in birth trends, and year of birth was compared with epidemic measles years between 1951 and 1967. Risk ratios with 95% confidence intervals (CI) and chi(2) tests were performed.
There were marginal differences between the birth dates of the CD patients and those predicted from the general population. Further analysis of both season of birth and year halves revealed a very weak association with the first half of the year (relative risk 1.14 (95% CI 1.01-1.30)). There was no association between developing CD and birth during measles epidemics between 1951 and 1967.
In utero or perinatal exposure to seasonal environmental factors are unlikely potential aetiological agents in the later development of CD.
克罗恩病（CD）发病率的上升表明环境因素在易感个体发病过程中发挥作用。围产期感染被认为是这样一种环境因素。
研究出生日期对日后CD发病的影响。
合并1972年至1989年确诊的4个CD患者登记册，并检查1624例患者的数据。将CD患者的出生日期与三个十年（1941 - 1950年、1951 - 1960年和1961 - 1970年）的全国出生数据进行比较，以避免出生趋势的时间变化，并将出生年份与1951年至1967年的麻疹流行年份进行比较。进行了95%置信区间（CI）的风险比和卡方检验。
CD患者的出生日期与根据普通人群预测的日期之间存在微小差异。对出生季节和半年的进一步分析显示，与上半年的关联非常弱（相对风险1.14（95%CI 1.01 - 1.30））。1951年至1967年麻疹流行期间出生与患CD之间无关联。
子宫内或围产期暴露于季节性环境因素不太可能是CD后期发病的潜在病因。
