So E L, Sam M C, Lagerlund T L
Section of Electroencephalography and the Division of Epilepsy, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA.
Epilepsia. 2000 Nov;41(11):1494-7. doi: 10.1111/j.1528-1157.2000.tb00128.x.
While undergoing video-EEG monitoring, a 20-year-old woman had a 56-second convulsive seizure, after which she developed persistent apnea. The rhythm of the electrocardiogram complexes was unimpaired for approximately 10 seconds, after which it gradually and progressively slowed until it stopped 57 seconds later. Evaluation after successful cardio-respiratory resuscitation showed no evidence of airway obstruction or pulmonary edema. The patient had a previous cardio-respiratory arrest after a complex partial seizure without secondary generalization. Although epileptic seizures are known to be potentially arrhythmogenic to the heart, our observations strongly suggest that one probable mechanism of sudden unexplained death in epilepsy is the marked central suppression of respiratory activity after seizures.
在接受视频脑电图监测时，一名20岁女性发生了一次持续56秒的惊厥性癫痫发作，之后出现了持续性呼吸暂停。心电图复合波的节律在大约10秒内未受影响，之后逐渐且持续减慢，直到57秒后停止。心肺复苏成功后的评估显示，没有气道阻塞或肺水肿的迹象。该患者曾在一次复杂部分性发作且无继发性全面发作后发生过心肺骤停。尽管已知癫痫发作可能对心脏产生致心律失常作用，但我们的观察强烈表明，癫痫猝死的一种可能机制是发作后呼吸活动受到显著的中枢抑制。
