Oka R K, De Marco T, Haskell W L, Botvinick E, Dae M W, Bolen K, Chatterjee K
University of California, Los Angeles School of Nursing, 90095-6918, USA.
Am J Cardiol. 2000 Feb 1;85(3):365-9. doi: 10.1016/s0002-9149(99)00748-1.
Patients with heart failure (HF) often have profound activity limitations and diminished quality of life (QOL) due to symptoms of dyspnea and fatigue. Although recent studies demonstrate positive physiologic and psychological benefits of low to moderate intensity, supervised, aerobic exercise training performed 3 to 5 days/ week for 20 to 40 minutes' duration, in a monitored setting, the efficacy of a home-based exercise program combining endurance and resistance exercise on symptoms and QOL, are unknown. This randomized controlled study examined the efficacy, safety, and adherence rates of a 3-month home-based combined walking and resistance exercise program on symptoms and QOL in 40 women and men aged 30 to 76 years with New York Heart Association class II to III HF. Baseline and 3-month evaluations consisted of a chronic HF questionnaire to assess symptoms and QOL and exercise capacity by symptom-limited treadmill exercise test with respiratory gas analysis. The exercise intervention improved fatigue (p = 0.02), emotional function (p = 0.01), and mastery (p = 0.04). Overall exercise adherence was excellent (90%) and there were no reported adverse events. A moderate intensity home-based combined walking and resistance program for patients with class II to III HF is safe and effective in reducing symptoms and improving QOL.
心力衰竭（HF）患者常因呼吸困难和疲劳症状而存在严重的活动受限，生活质量（QOL）下降。尽管最近的研究表明，在有监测的环境中，每周进行3至5天、每次持续20至40分钟的低至中等强度、有监督的有氧运动训练，对生理和心理有积极益处，但结合耐力和阻力运动的家庭锻炼计划对症状和生活质量的疗效尚不清楚。这项随机对照研究调查了一项为期3个月的家庭联合步行和阻力运动计划，对40名年龄在30至76岁、纽约心脏协会II至III级心力衰竭的男性和女性的症状和生活质量的疗效、安全性和依从率。基线和3个月评估包括一份慢性心力衰竭问卷，以通过症状限制的跑步机运动测试和呼吸气体分析来评估症状、生活质量和运动能力。运动干预改善了疲劳（p = 0.02）、情绪功能（p = 0.01）和掌控感（p = 0.04）。总体运动依从性良好（90%），且未报告不良事件。对于II至III级心力衰竭患者，中等强度的家庭联合步行和阻力运动计划在减轻症状和改善生活质量方面是安全有效的。
