Larsson H, Lindgärde F, Berglund G, Ahrén B
Department of Medicine, Malmö University Hospital, Sweden.
Diabetologia. 2000 Oct;43(10):1224-8. doi: 10.1007/s001250051516.
AIMS/HYPOTHESIS: To study the risk of women with impaired fasting glucose (IFG) as against impaired glucose tolerance (IGT) developing diabetes.
Oral glucose tolerance tests (75 g) were done in 265 women selected at random at baseline (age 55-57 years) and at a 10-year follow-up. Of the women 42 had IFG/NGT (fasting glucose 6.1-6.9 mmol/l, 2-h glucose < 7.8 mmol/l), 66 IGT/ NFG (2-h glucose 7.8-11.0 mmol/l, fasting glucose < 6.1 mmol/1), 30 IGT/IFG and 127 NFG/NGT.
The 10-year progression to diabetes was similar in IGT/NFG (12.1%) and IFG/NGT groups (11.9%, p = 0.97). In IGT/IFG, 20.0% had developed diabetes, which was not significantly higher than in IFG/NGT and IGT/NFG (p = 0.53). In NFG/ NGT at baseline, only 3.9 % had developed diabetes, which was lower than in the other groups (p = 0.023).
CONCLUSION/INTERPRETATION: Fasting and 2-h glucose concentrations are equally good in predicting diabetes development over a 10-year period in Caucasian postmenopausal women. Because IGT is more common than IFG, measuring only fasting glucose concentrations would, however, result in missing a prediabetic stage in a large group of people at risk for diabetes and cardiovascular diseases.
目的/假设：研究空腹血糖受损（IFG）女性与糖耐量受损（IGT）女性患糖尿病的风险。
对265名随机选取的女性进行口服葡萄糖耐量试验（75克），这些女性在基线时（年龄55 - 57岁）及10年随访时接受测试。其中42名女性为IFG/NGT（空腹血糖6.1 - 6.9毫摩尔/升，2小时血糖<7.8毫摩尔/升），66名女性为IGT/NFG（2小时血糖7.8 - 11.0毫摩尔/升，空腹血糖<6.1毫摩尔/升），30名女性为IGT/IFG，127名女性为NFG/NGT。
IGT/NFG组（12.1%）和IFG/NGT组（11.9%，p = 0.97）10年发展为糖尿病的情况相似。IGT/IFG组中，20.0%发展为糖尿病，这与IFG/NGT组和IGT/NFG组相比无显著差异（p = 0.53）。基线时NFG/NGT组中，只有3.9%发展为糖尿病，低于其他组（p = 0.023）。
结论/解读：在白种绝经后女性中，空腹血糖和2小时血糖浓度在预测10年内糖尿病发展方面同样有效。然而，由于IGT比IFG更常见，仅测量空腹血糖浓度会导致一大群有糖尿病和心血管疾病风险的人错过糖尿病前期阶段。
