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携带温度敏感突变“麻痹（shibire）”的黑腹果蝇神经肌肉接头处的可逆性改变

Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire.

作者信息

Poodry C A, Edgar L

出版信息

J Cell Biol. 1979 Jun;81(3):520-7. doi: 10.1083/jcb.81.3.520.

DOI:10.1083/jcb.81.3.520
PMID:110817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2110401/
Abstract

In this study we report a relationship between the ultrastruct of the neuromuscular junctions of tibial muscles and the temperature-induced paralysis in shibire flies. There is a decrease in the number of synaptic vesicles of neuromuscular junctions in flies which are held at or above 29 degrees. Shortly after return to 22 degrees C, the synaptic vesicles are again present in large numbers. Prior treatment with tetrodotoxin or barbiturate protects the junctions from the temperature change in morphology.

摘要

在本研究中，我们报告了果蝇胫节肌肉神经肌肉接头的超微结构与温度诱导的麻痹之间的关系。在29摄氏度及以上温度下饲养的果蝇，其神经肌肉接头处的突触小泡数量减少。回到22摄氏度后不久，突触小泡再次大量出现。用河豚毒素或巴比妥酸盐预先处理可保护接头免受形态学上的温度变化影响。

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本文引用的文献

1
The effects of increased temperature on electroretinograms of temperature-sensitive paralysis mutants of Drosophila melanogaster.温度升高对黑腹果蝇温度敏感麻痹突变体视网膜电图的影响。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4906-9. doi: 10.1073/pnas.71.12.4906.
2
Developmental properties of Shibire: a pleiotropic mutation affecting larval and adult locomotion and development.“Shibire”的发育特性：一种影响幼虫和成虫运动及发育的多效性突变。
Dev Biol. 1973 Jun;32(2):373-86. doi: 10.1016/0012-1606(73)90248-0.
3
Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.黑腹果蝇温度敏感型麻痹突变体的神经生理缺陷
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3253-7. doi: 10.1073/pnas.73.9.3253.