Kotzbach R, Kłyszejko C, Sobociński Z, Włodarczyk L, Kotzbach M
Katedry i Kliniki Połoznictwa i Chorób Kobiecych AM w Bydgoszczy.
Ginekol Pol. 2000 Aug;71(8):859-62.
In the research an evaluation was made of the effectiveness of immunoprophylaxis applied in fetomaternal incompatibility in the range of antigen D. Material was based on patients who were delivered in the Clinic of Obstetrics and Gynaecology, Medical Academy in Bydgoszcz in the years 1981-1999. In that period of time there were 46,398 deliveries. 6217 pregnancies were found to be serologically incompatible in the range of antigen D. In 5384 patients immunoglobulin anti D was administered at a dose of 15-300 micrograms. At one time 311 patients with serological conflict in the range of antigen D were treated. Postpartum immunoprophylaxis was found effective in 93.9%. Lak of compliance with the principles of immunoprophylaxis, especially in patients after a miscarriage, and too low doses of Ig anti D were recognised as the reasons for incomplete effectiveness.
在这项研究中，对应用于抗原D范围内母胎不相容的免疫预防效果进行了评估。材料基于1981年至1999年在比得哥什医学院妇产科诊所分娩的患者。在那段时间里，共有46398例分娩。发现6217例妊娠在抗原D范围内血清学不相容。在5384例患者中，给予了剂量为15至300微克的抗D免疫球蛋白。一次治疗了311例在抗原D范围内存在血清学冲突的患者。产后免疫预防的有效率为93.9%。未遵守免疫预防原则，尤其是流产后患者，以及抗D免疫球蛋白剂量过低被认为是效果不完全的原因。
