Polak G, Kozioł-Montewka M, Tarkowski R, Morawska D, Kotarski J
Katedry i Zakładu Mikrobiologii Lekarskiej AM w Lublinie.
Ginekol Pol. 2000 Sep;71(9):1017-21.
To assess the concentration of Plasma Glutathione Peroxidase (plGPx) in the peritoneal fluid (PF) of patients with unexplained infertility and infertile women with minimal and mild endometriosis.
33 women were studied, including 8 infertile women with minimal or mild endometriosis, 15 patients with unexplained infertility and 10 patients with tubal occlusion (a reference group). Concentration of plGPx was measured in the PF using a commercially available ELISA kit (Oxis Inc.).
The plGPx concentration was significantly (p = 0.04) lower in PF from women with unexplained infertility (846 +/- 177 ng/ml) compared to the reference group (1023 +/- 238 ng/ml), but did not differ significantly (p = 0.25) between women with endometriosis (918 +/- 81 ng/ml) and patients with tubal infertility.
Our results suggest that low peritoneal plGPx concentration may play a role in the pathogenesis of infertility.
评估不明原因不孕症患者以及患有轻微和轻度子宫内膜异位症的不孕女性腹腔液中血浆谷胱甘肽过氧化物酶（plGPx）的浓度。
研究了33名女性，包括8名患有轻微或轻度子宫内膜异位症的不孕女性、15名不明原因不孕症患者以及10名输卵管阻塞患者（作为参照组）。使用市售酶联免疫吸附测定试剂盒（Oxis公司）测定腹腔液中plGPx的浓度。
与参照组（1023±238纳克/毫升）相比，不明原因不孕症女性腹腔液中的plGPx浓度显著降低（p = 0.04）（846±177纳克/毫升），但子宫内膜异位症女性（918±81纳克/毫升）与输卵管性不孕症患者之间差异不显著（p = 0.25）。
我们的结果表明，腹腔液中plGPx浓度低可能在不孕症发病机制中起作用。
