Polak G, Kozioł-Montewka M, Tarkowski R, Kotarski J
I Katedry i Kliniki Ginekologii Operacyjnej AM w Lublinie.
Ginekol Pol. 2001 Dec;72(12A):1316-20.
To investigate the possible role of oxidative stress in the pathogenesis of female infertility, we examined the peritoneal fluid (PF) and plasma lipid peroxides levels in infertile women.
4-hydroxynonenal (4-HNE) and malonyldialdehyde (MDA) concentrations were measured in peritoneal fluid and plasma samples obtained from: 10 infertile women with minimal and mild endometriosis, 24 patients with unexplained infertility, 11 women with PCOS and 14 patients with tubal infertility.
PF lipid peroxides level was significantly higher in women with idiopathic infertility compared to other groups. Plasma 4-HNE and MDA concentrations did not differ significantly between the infertile groups. No significant difference or relationship was observed between peritoneal fluid and plasma lipid peroxides levels.
Increased free radicals activity in the peritoneal fluid environment may be the factor responsible for some cases of "unexplained infertility".
为研究氧化应激在女性不孕症发病机制中的可能作用，我们检测了不孕女性的腹腔液（PF）和血浆脂质过氧化物水平。
测量了从以下对象获取的腹腔液和血浆样本中的4-羟基壬烯醛（4-HNE）和丙二醛（MDA）浓度：10例轻度和中度子宫内膜异位症的不孕女性、24例不明原因不孕症患者、11例多囊卵巢综合征女性以及14例输卵管性不孕症患者。
与其他组相比，特发性不孕症女性的腹腔液脂质过氧化物水平显著更高。不孕组之间血浆4-HNE和MDA浓度无显著差异。腹腔液和血浆脂质过氧化物水平之间未观察到显著差异或相关性。
腹腔液环境中自由基活性增加可能是某些“不明原因不孕症”病例的致病因素。
