Su W, Ko A, O'Connell T, Applebaum H
Department of Surgery, Kaiser Permanente Medical Center, Los Angeles, CA 90029, USA.
J Pediatr Surg. 2000 Nov;35(11):1635-7. doi: 10.1053/jpsu.2000.18340.
Large inflammatory pseudotumors (IPT) traditionally are managed with extensive surgical resection. This approach, which often is associated with significant morbidity, has been deemed necessary because of the uncertainty of diagnosis, symptomatology, and involvement of vital structures. Also, there is a lack of other reliable therapy for this clinically aggressive yet histologically benign disease characterized by an overreactive inflammatory response. The authors treated 2 cases of abdominal IPT with nonsteroidal antiinflammatory drug (NSAID) with successful results. After a diagnosis of IPT on tumor biopsy, an NSAID trial can confirm the diagnosis and treat the disease by causing tumor shrinkage and eventual resolution. Excision remains indicated in easily resectable tumors and in nonresponders to NSAID therapy.
传统上，大型炎性假瘤（IPT）通过广泛的手术切除进行治疗。由于诊断、症状以及重要结构受累情况的不确定性，这种通常会导致显著发病率的方法被认为是必要的。此外，对于这种以过度反应性炎症反应为特征的临床侵袭性但组织学上为良性的疾病，缺乏其他可靠的治疗方法。作者用非甾体抗炎药（NSAID）治疗了2例腹部IPT，取得了成功。在肿瘤活检确诊为IPT后，NSAID试验可以通过使肿瘤缩小并最终消退来确诊并治疗该疾病。对于易于切除的肿瘤以及对NSAID治疗无反应者，仍需进行切除。
