Margarit C, Bilbao I, Charco R, Lázaro J L, Hidalgo E, Allende E, Murio E
Department of Surgery, Liver Transplantation Unit, Hospital General Vall Hebrón, Universidad Autónoma Barcelona, Barcelona, Spain.
Liver Transpl. 2000 Nov;6(6):805-9. doi: 10.1053/jlts.2000.18492.
Auxiliary liver transplantation for patients with fulminant hepatic failure supports the patient's failing liver for a period of time until the native liver (NL) has recovered and immunosuppression can be withdrawn. Auxiliary heterotopic liver transplantation (AHLT) with portal vein arterialization (PVA) has several advantages over auxiliary orthotopic liver transplantation: NL resection is not required, and the hepatic hilum is left untouched; thus, the chances of liver regeneration are optimal. The successful application of emergency AHLT with PVA in a young patient who developed toxic fulminant hepatic failure caused by tuberculostatic drugs is described. Two and one-half months after the procedure, the NL had completely regenerated; the graft was removed, and immunosuppression was suspended.
对于暴发性肝衰竭患者，辅助性肝移植可在一段时间内支持患者衰竭的肝脏，直至自体肝脏（NL）恢复且可停用免疫抑制治疗。与辅助性原位肝移植相比，门静脉动脉化（PVA）辅助性异位肝移植（AHLT）具有多个优势：无需切除NL，肝门保持完整；因此，肝脏再生的机会最佳。本文描述了紧急PVA-AHLT在一名因抗结核药物导致中毒性暴发性肝衰竭的年轻患者中的成功应用。术后两个半月，NL完全再生；移除移植物并停用免疫抑制治疗。
