Popper H
Am J Pathol. 1975 Dec;81(3):609-28.
In clinical pathologic correlations, including the potential effect of the virus on the liver, the morphologic features of the various stages of viral hepatitis are the firm information available today. With acute hepatitis being an inflammatory reaction to cell injury and necrosis, and chronic hepatitis being sustained inflammation, correlation with clinical features and functional defects is good in acute hepatitis and less so in the chronic stages. The pathogenesis of the diseases-including cell necrosis, inflammation, fibrosis, and cirrhosis formation-is reasonably well understood, and this knowledge assists both in prognosis and in monitoring of therapy. The localization of the components of the hepatitis B antigen and their effects, including the nature of the immune response, is the most exciting aspect of the clinical pathologic problem. Today's interpretations offer, at best, a working hypothesis promising further understanding of the evolution of the disease.
在临床病理相关性研究中，包括病毒对肝脏的潜在影响，病毒性肝炎各阶段的形态学特征是目前可得的确切信息。急性肝炎是对细胞损伤和坏死的炎症反应，而慢性肝炎是持续的炎症，急性肝炎与临床特征和功能缺陷的相关性良好，而在慢性阶段则较弱。这些疾病的发病机制，包括细胞坏死、炎症、纤维化和肝硬化形成，已得到相当好的理解，这一知识有助于预后评估和治疗监测。乙型肝炎抗原成分的定位及其影响，包括免疫反应的性质，是临床病理问题中最令人兴奋的方面。目前的解释充其量只是一个可行的假设，有望进一步了解疾病的演变。
