Shin D Y, Kim H S, Min K H, Hyun S S, Kim S A, Huh H, Choi E C, Choi Y H, Kim J, Choi S H, Kim W B, Suh Y G
College of Pharmacy, Seoul National University, Kwanak-Gu, Korea.
Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1805-6. doi: 10.1248/cpb.48.1805.
A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 microg/ml which is comparable to that of vancomycin.
从韩国传统上用于治疗传染病的光叶榉中分离出了一种高效抗耐甲氧西林金黄色葡萄球菌（MRSA）的倍半萜类化合物。这种天然存在的抗生素被鉴定为曼森酮F（1）。已发现该化合物对MRSA具有高度特异性活性，其最低抑菌浓度（MIC）范围为0.39 - 3.13微克/毫升，与万古霉素相当。
