严重脑膜炎球菌感染中的低钙血症
Hypocalcaemia in severe meningococcal infections.
作者信息
Baines P B, Thomson A P, Fraser W D, Hart C A
机构信息
Paediatric Intensive Care Unit, Royal Liverpool Children's Hospital, Eaton Rd, Liverpool L12 2AP, UK.
出版信息
Arch Dis Child. 2000 Dec;83(6):510-3. doi: 10.1136/adc.83.6.510.
AIM
To determine the incidence of hypocalcaemia in critically ill children with meningococcal disease.
METHODS
In a prospective cohort study, 70 of 80 patients admitted consecutively with a clinical diagnosis of meningococcal disease to intensive care had measurements of total and ionised calcium on admission. Parathormone and calcitonin were measured in a proportion of the children.
RESULTS
Total and ionised calcium concentrations were low in 70% of the children. There was a weak relation of calcium concentration to the volume of blood derived colloid which had been given, but a good relation to disease severity, where sicker children had lower calcium concentrations. Although the parathormone concentration was higher in children with lower calcium concentrations, some children had low ionised calcium concentrations, without an increase of parathormone concentration. Serum calcitonin concentration was not related to calcium concentrations.
CONCLUSION
Hypocalcaemia is common in meningococcal disease.
目的
确定患脑膜炎球菌病的危重症儿童低钙血症的发生率。
方法
在一项前瞻性队列研究中，80例临床诊断为脑膜炎球菌病并入住重症监护病房的患者中有70例在入院时测量了总钙和离子钙水平。部分儿童还测量了甲状旁腺激素和降钙素水平。
结果
70%的儿童总钙和离子钙浓度较低。钙浓度与输入的血液代用胶体量之间关系较弱，但与疾病严重程度密切相关，病情较重的儿童钙浓度较低。虽然钙浓度较低的儿童甲状旁腺激素浓度较高，但一些儿童离子钙浓度较低，而甲状旁腺激素浓度并未升高。血清降钙素浓度与钙浓度无关。
结论
低钙血症在脑膜炎球菌病中很常见。
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