Rafin C, Veignie E, Sancholle M, Postel D, Len C, Villa P, Ronco G
Laboratoire de Chimie Organique et Cinétique, Université de Picardie-Jules Verne, 80039 Amiens, France.
J Agric Food Chem. 2000 Nov;48(11):5283-7. doi: 10.1021/jf0003698.
Novel carbamic esters possessing a carbohydrate moiety derived from glycerol or D-glucose with two N,N-diethyldithiocarbamoyl groups and a series of bisdithiocarbamic esters having a ketone or an alkyl ester have been synthesized. The in vitro activity of these new compounds was evaluated against Fusarium oxysporum f. sp. lini. Some of the compounds [bis[1,3-S-(N,N-diethyldithiocarbamoyl)]-1, 3-dideoxyglycerol) and diethyl N,N'-(1,3-dideoxyglycer-1, 3-diyl)bis(dithiocarbamate)] were more active for inhibiting vegetative mycelium growth than, respectively, the commercial N, N-diethyldithiocarbamic acid sodium salt and Maneb. The structure activity of these new compounds is discussed.
已合成了具有源自甘油或D -葡萄糖的碳水化合物部分且带有两个N,N -二乙基二硫代氨基甲酰基的新型氨基甲酸酯，以及一系列具有酮或烷基酯的双二硫代氨基甲酸酯。评估了这些新化合物对尖孢镰刀菌亚麻专化型的体外活性。其中一些化合物[双[1,3 - S - (N,N -二乙基二硫代氨基甲酰基)] - 1,3 -二脱氧甘油和N,N' - (1,3 -二脱氧甘油 - 1,3 -二基)双(二硫代氨基甲酸盐)二乙酯]分别比市售的N,N -二乙基二硫代氨基甲酸钠盐和代森锰锌对抑制营养菌丝体生长更具活性。讨论了这些新化合物的构效关系。
