D'Agostino R L, Tilton R C
Ann Clin Lab Sci. 1976 Jan-Feb;6(1):104-9.
Twelve strains of Haemophilus influenzae were tested for susceptibility to gentamicin, ampicillin, chloramphenicol and cephalothin using two methods, agar dilution and microdilution (broth). Although inocula and incubation conditions were standardized, significant differences in the minimal inhibitory concentration (MIC) were seen as a result of growth media. Method dependent differences were also observed for some antibiotics. Notwithstanding such variation, high level resistance of H. influenzae to ampicillin was readily detected by either broth or agar dilution tests.
采用琼脂稀释法和微量稀释法（肉汤法）对12株流感嗜血杆菌进行了庆大霉素、氨苄西林、氯霉素和头孢噻吩的药敏试验。尽管接种物和培养条件已标准化，但由于生长培养基的原因，最小抑菌浓度（MIC）仍存在显著差异。对于某些抗生素，还观察到了方法依赖性差异。尽管存在这种差异，但通过肉汤或琼脂稀释试验都能很容易地检测到流感嗜血杆菌对氨苄西林的高水平耐药性。
