Peters J H, Gordon G R, Murray J F, Fieldsteel A H, Levy L
Antimicrob Agents Chemother. 1975 Nov;8(5):551-7. doi: 10.1128/AAC.8.5.551.
To define the minimal inhibitory concentration (MIC) of dapsone (DDS) for Mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads with M. leprae. The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS for M. leprae in rats are nearly identical to the previously determined MIC of DDS for M. leprae in mice.
为确定氨苯砜（DDS）对大鼠体内麻风分枝杆菌的最低抑菌浓度（MIC），我们测定了未感染的雄性和雌性Lewis大鼠饮食中DDS水平与血浆中DDS水平之间的关系。这一知识被应用于设计用麻风分枝杆菌接种大鼠足垫的实验。雄性和雌性大鼠中DDS的MIC分别为血浆中1.5至4.0 ng DDS/ml和1.8至3.0 ng DDS/ml，尽管在摄入相同饮食水平的DDS时，两性的DDS浓度存在显著差异。大鼠中DDS对麻风分枝杆菌的MIC值与先前测定的小鼠中DDS对麻风分枝杆菌的MIC值几乎相同。
