Yang H, Mujtaba T, Venkatraman G, Wu Y Y, Rao M S, Luskin M B
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13366-71. doi: 10.1073/pnas.97.24.13366.
Spinal cord neuronal restricted progenitor (NRP) cells, when transplanted into the neonatal anterior forebrain subventricular zone, migrate to distinct regions throughout the forebrain including the olfactory bulb, frontal cortex, and occipital cortex but not to the hippocampus. Their migration pattern and differentiation potential is distinct from anterior forebrain subventricular zone NRPs. Irrespective of their final destination, NRP cells do not differentiate into glia. Rather they synthesize neurotransmitters, acquire region-specific phenotypes, and receive synapses from host neurons after transplantation. Spinal cord NRPs express choline acetyl transferase even in regions where host neurons do not express this marker. The restricted distribution of transplanted spinal cord NRP cells and their acquisition of varied region-specific phenotypes suggest that their ultimate fate and phenotype is dictated by a combination of intrinsic properties and extrinsic cues from the host.
脊髓神经元限制性前体细胞（NRP）移植到新生动物前脑腹侧脑室下区后，会迁移至整个前脑的不同区域，包括嗅球、额叶皮质和枕叶皮质，但不会迁移至海马体。它们的迁移模式和分化潜能与前脑腹侧脑室下区的NRP不同。无论最终目的地如何，NRP细胞都不会分化为神经胶质细胞。相反，它们合成神经递质，获得区域特异性表型，并在移植后接受来自宿主神经元的突触。即使在宿主神经元不表达该标志物的区域，脊髓NRP也会表达胆碱乙酰转移酶。移植的脊髓NRP细胞的局限性分布及其获得的多种区域特异性表型表明，它们的最终命运和表型是由内在特性和来自宿主的外在信号共同决定的。
