Matsuyama M, Yamazaki O, Horii K, Higaki I, Kawai S, Mikami S, Higashino M, Oka H, Nakai T, Inoue T
Department of Surgery, Osaka City General Hospital, Osaka, Japan.
J Surg Oncol. 2000 Nov;75(3):197-202. doi: 10.1002/1096-9098(200011)75:3<197::aid-jso8>3.0.co;2-i.
A case of erythrocytosis caused by a hepatocellular carcinoma (HCC) that produced erythropoietin (Epo) is described. A 64-year-old man, with a huge HCC tumor in the right lobe of the liver, showed a high concentration of hemoglobin and increased levels of serum Epo, alpha-fetoprotein (AFP), and protein induced by vitamin K absence II (PIVKA-II). Right lobectomy of the liver was performed. Histological findings of the specimen showed a moderately differentiated HCC. The existence of Epo was confirmed immunohistochemically only in the tumor tissue and not in the normal liver tissue. Erythrocytosis disappeared and the serum levels of Epo, AFP, and PIVKA-II returned to the normal range after the operation. Within 2 months after the operation, recurrent tumors appeared in the remnant liver, and the patient died 13 months after the operation.
本文描述了一例由产生促红细胞生成素（Epo）的肝细胞癌（HCC）引起的红细胞增多症病例。一名64岁男性，肝脏右叶有巨大的HCC肿瘤，血红蛋白浓度高，血清Epo、甲胎蛋白（AFP）和维生素K缺乏诱导蛋白II（PIVKA-II）水平升高。实施了肝脏右叶切除术。标本的组织学检查结果显示为中度分化的HCC。仅在肿瘤组织中通过免疫组织化学证实存在Epo，而在正常肝组织中未发现。术后红细胞增多症消失，Epo、AFP和PIVKA-II的血清水平恢复到正常范围。术后2个月内，残余肝脏出现复发性肿瘤，患者术后13个月死亡。
