1993年2月1日至1994年1月31日加拿大结核分枝杆菌耐药性研究
Drug resistance study of Mycobacterium tuberculosis in Canada, February 1, 1993 to January 31, 1994.
作者信息
Farzad E, Holton D, Long R, FitzGerald M, Laszlo A, Njoo H, Fanning A, Hershfield E, Hoeppner V, Allen E
机构信息
Division of Blood Borne Pathogens, LCDC, Ottawa.
出版信息
Can J Public Health. 2000 Sep-Oct;91(5):366-70. doi: 10.1007/BF03404809.
OBJECTIVE
To estimate the prevalence of resistance of Mycobacterium tuberculosis to first-line antituberculosis drugs in Canada.
METHODS
M. tuberculosis isolates from one third of all culture-positive tuberculosis (TB) cases diagnosed between February 1, 1993 to January 31, 1994 in Canada were collected prospectively. Proportion of drug-resistant isolates and the factors related to drug resistance were measured.
RESULTS
Of 458 study cases, 40 (8.7%) had resistance to at least one first-line antituberculosis drug, of which 5.9% had mono-resistance, 0.7% had multidrug-resistance(MDR-TB)--i.e., resistance to at least isoniazid and rifampin--and 2.2% had other patterns. The overall prevalence of resistance among the foreign-born cases was 10.6% with the highest level among those who resided in Canada for less than four years (15.5%).
CONCLUSIONS
Canada has a relatively low prevalence of antituberculosis drug resistance and a very low prevalence of MDR-TB. Some new immigrants to Canada may be at higher risk for drug resistance and their initial treatment needs to be tailored accordingly.
目的
评估加拿大结核分枝杆菌对一线抗结核药物的耐药率。
方法
前瞻性收集1993年2月1日至1994年1月31日期间在加拿大诊断出的所有培养阳性结核病（TB）病例中三分之一的结核分枝杆菌分离株。测定耐药分离株的比例以及与耐药相关的因素。
结果
在458例研究病例中，40例（8.7%）对至少一种一线抗结核药物耐药，其中5.9%为单耐药，0.7%为耐多药（MDR-TB），即至少对异烟肼和利福平耐药，2.2%为其他耐药模式。外国出生病例的总体耐药率为10.6%，在加拿大居住不到四年的人群中耐药率最高（15.5%）。
结论
加拿大抗结核药物耐药率相对较低，耐多药结核病患病率极低。一些加拿大新移民可能耐药风险较高，需要据此调整其初始治疗方案。
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