Daldrup-Link H E, Shames D M, Wendland M, Mühler A, Gossmann A, Rosenau W, Brasch R C
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California, San Francisco 94243, USA.
Acad Radiol. 2000 Nov;7(11):934-44. doi: 10.1016/s1076-6332(00)80175-0.
This study compared gadopentetate dimeglumine (molecular weight, 0.5 kD), a standard contrast medium, and Gadomer-17 (apparent molecular weight, approximately 35 kD), a new, clinically applicable, large-molecular contrast medium, with respect to their microvascular characterizations of experimentally induced breast tumors at magnetic resonance (MR) imaging.
A spectrum of breast tumors, benign through highly malignant, was induced in Sprague-Dawley rats (n = 30) by intraperitoneal administration of N-ethyl-N-nitrosourea (ENU), a potent carcinogen. All animals underwent three-dimensional spoiled gradient-recalled MR imaging, with precontrast imaging and dynamic postcontrast imaging after injection of gadopentetate dimeglumine (0.1 mmol/kg) and Gadomer-17 (0.03 mmol/kg), administered in a random order at a 24-hour interval. Several microvascular parameters were compared: the endothelial transfer coefficient (K(PS)), a measure of microvascular permeability; the fractional plasma volume (fPV), and the plasma equivalent volume. Each MR imaging parameter was correlated with histopathologic findings.
With Gadomer-17, the mean values for K(PS) and fPV were significantly greater in carcinomas than in fibroadenomas (P < .004 and .04, respectively). With gadopentetate dimeglumine, the mean values for fPV and PEV were significantly greater in carcinomas (P <. 004 and .02, respectively). Because of the high variability within both fibroadenoma and carcinoma groups, however, there were no significant correlations between K(PS), fPV, or PEV and histopathologic tumor grade as indicated by the Scarff-Bloom-Richardson score, for either agent.
Although the K(PS) and fPV estimates obtained from dynamic MR imaging data with Gadomer-17 enhancement offer some potential for characterizing breast tumors, none of the quantitative microvascular parameters derived with either agent were significantly correlated with histopathologic tumor grade.
本研究比较了标准造影剂钆喷酸葡胺（分子量0.5kD）和一种新型的、临床可用的大分子造影剂Gadomer-17（表观分子量约35kD）在磁共振（MR）成像中对实验性诱导的乳腺肿瘤微血管特征的表现。
通过腹腔注射强效致癌物N-亚硝基-N-乙基脲（ENU）在30只Sprague-Dawley大鼠中诱导出一系列从良性到高度恶性的乳腺肿瘤。所有动物均接受三维扰相梯度回波MR成像，在注射钆喷酸葡胺（0.1mmol/kg）和Gadomer-17（0.03mmol/kg）后进行对比前成像和动态对比后成像，两种造影剂以随机顺序在24小时间隔内给药。比较了几个微血管参数：内皮转运系数（K(PS)），一种微血管通透性的测量指标；血浆分数体积（fPV）以及血浆等效体积。每个MR成像参数都与组织病理学结果相关。
使用Gadomer-17时，癌组织中K(PS)和fPV的平均值显著高于纤维腺瘤（分别为P <.004和.04）。使用钆喷酸葡胺时，癌组织中fPV和PEV的平均值显著更高（分别为P <.004和.02）。然而，由于纤维腺瘤和癌组织组内的高变异性，对于这两种造影剂中的任何一种，K(PS)、fPV或PEV与由斯卡夫-布鲁姆-理查森评分所表示的组织病理学肿瘤分级之间均无显著相关性。
尽管从Gadomer-17增强的动态MR成像数据中获得的K(PS)和fPV估计值在表征乳腺肿瘤方面具有一定潜力，但使用这两种造影剂得出的任何定量微血管参数均与组织病理学肿瘤分级无显著相关性。
