Sponheim S R, Clementz B A, Iacono W G, Beiser M
Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Biol Psychiatry. 2000 Dec 1;48(11):1088-97. doi: 10.1016/s0006-3223(00)00907-0.
This study investigated the clinical and biological concomitants of electroencephalogram power abnormalities in schizophrenia.
We examined the power characteristics of resting electroencephalograms in 112 schizophrenic patients. Also collected were measures of psychotic symptomatology, brain morphology, ocular motor functioning, electrodermal activity, and nailfold plexus visibility. Seventy-eight nonschizophrenic psychosis patients (e.g., mood disorder patients with psychosis) and 107 nonpsychiatric control subjects were included for comparison.
Schizophrenic patients whose electroencephalograms were characterized by augmented low-frequency power and diminished alpha-band power had more negative symptoms, larger third ventricles, larger frontal horns of the lateral ventricles, increased cortical sulci widths, and greater ocular motor dysfunction compared with schizophrenic patients without these electroencephalogram characteristics. In nonschizophrenic psychosis patients, augmented low-frequency and diminished alpha-band powers failed to be associated with any clinical or biological indices.
Results suggest that clinical and biological concomitants of low-frequency and alpha-band power abnormalities in schizophrenia are unique, perhaps indicating the presence of thalamic and frontal lobe dysfunction.
本研究调查了精神分裂症患者脑电图功率异常的临床和生物学伴随情况。
我们检查了112例精神分裂症患者静息脑电图的功率特征。还收集了精神病症状学、脑形态学、眼动功能、皮肤电活动和甲襞微循环可见度的测量数据。纳入了78例非精神分裂症性精神病患者（如伴有精神病的情绪障碍患者）和107例非精神病对照者进行比较。
与不具有这些脑电图特征的精神分裂症患者相比，脑电图表现为低频功率增强和α波段功率降低的精神分裂症患者有更多的阴性症状、第三脑室更大、侧脑室额角更大、皮质沟回增宽以及眼动功能障碍更严重。在非精神分裂症性精神病患者中，低频功率增强和α波段功率降低与任何临床或生物学指标均无关联。
结果表明，精神分裂症患者低频和α波段功率异常的临床和生物学伴随情况是独特的，这可能表明存在丘脑和额叶功能障碍。
