大鼠短波长光诱导的视网膜损伤
Short wavelength light-induced retinal damage in rats.
作者信息
Masuda K, Watanabe I
机构信息
Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
出版信息
Jpn J Ophthalmol. 2000 Nov-Dec;44(6):615-9. doi: 10.1016/s0021-5155(00)00285-9.
PURPOSE
To evaluate short wavelength light-induced retinal damage in rats.
METHODS
Pigmented rats were exposed to 300-500 nm wavelength light for 30 seconds, 1, 3, 10, 20, 60, or 90 minutes. Electroretinogram a-, b-, and c-waves were recorded 48 hours after the exposure.
RESULTS
While the a- and b-wave amplitudes were reduced significantly after exposures of 60 minutes and longer, the c-wave amplitude was reduced after only 3 minutes of exposure.
CONCLUSIONS
Rat retinal pigment epithelium is more sensitive to damage by exposure to 300-500 nm wavelength light than the neural retina.
目的
评估短波长光对大鼠视网膜的损伤。
方法
将有色大鼠暴露于波长为300 - 500 nm的光下30秒、1、3、10、20、60或90分钟。在暴露后48小时记录视网膜电图的a波、b波和c波。
结果
暴露60分钟及更长时间后，a波和b波振幅显著降低，而仅暴露3分钟后c波振幅就降低了。
结论
大鼠视网膜色素上皮对300 - 500 nm波长光暴露造成的损伤比神经视网膜更敏感。
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