Wu L L, Suzuki Y, Ideta R, Araie M
Department of Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan.
Jpn J Ophthalmol. 2000 Nov-Dec;44(6):643-7. doi: 10.1016/s0021-5155(00)00275-6.
To compare central corneal thickness (CCT) of patients with normal tension glaucoma (NTG) with that of age-matched normal subjects, patients with open-angle glaucoma (POAG) and ocular hypertension (OH) subjects in Japan.
Central corneal thickness was measured in 79 NTG, 61 POAG, 73 OH, and 50 normal subjects with an ultrasonic pachymeter. One eye for 1 subject randomly selected in each group was used for inter-group comparison. The relationship between CCT and the maximum intraocular pressure (IOP) measured by Goldmann applanation tonometer with no ocular hypotensive medication (NTG, OH, and normal subjects) or under medication (POAG patients) was analyzed.
The CCT of OH subjects (582 +/- 32 microm; mean +/- SD) was significantly greater than that of the other groups (P <.001), while no difference was seen in CCT among normal (552 +/- 36 microm), NTG (548 +/- 33 microm) and POAG (550 +/- 33 microm) subjects. In normal subjects, CCT and the maximum IOP were significantly correlated but the correlation coefficient was small (r = 0.420, P <.05).
Central corneal thickness shows no significant difference among NTG, POAG, and normal subjects in Japan, while it is significantly greater in OH subjects. The CCT has little influence on the diagnosis of NTG in Japan.
比较日本正常眼压性青光眼（NTG）患者与年龄匹配的正常受试者、开角型青光眼（POAG）患者及高眼压症（OH）患者的中央角膜厚度（CCT）。
使用超声角膜测厚仪测量79例NTG患者、61例POAG患者、73例OH患者及50例正常受试者的中央角膜厚度。每组随机选取1名受试者的1只眼睛用于组间比较。分析CCT与使用Goldmann压平眼压计在未使用降眼压药物时（NTG、OH及正常受试者）或使用药物时（POAG患者）测量的最高眼压（IOP）之间的关系。
OH患者的CCT（582±32微米；平均值±标准差）显著高于其他组（P<.001），而正常受试者（552±36微米）、NTG患者（548±33微米）和POAG患者（550±33微米）之间的CCT无差异。在正常受试者中，CCT与最高眼压显著相关，但相关系数较小（r = 0.420，P<.05）。
在日本，NTG、POAG和正常受试者之间的中央角膜厚度无显著差异，而OH患者的中央角膜厚度显著更大。在日本，CCT对NTG诊断的影响较小。
