从基因转移方法中吸取的经验教训。
Lessons learned from gene transfer approaches.
作者信息
Evans C H, Ghivizzani S C, Lechman E R, Mi Z, Jaffurs D, Robbins P D
机构信息
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
出版信息
Arthritis Res. 1999;1(1):21-4. doi: 10.1186/ar6. Epub 1999 Jul 8.
Abstract
Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools for the study of synovitis and other aspects of the biology of joints in health and disease. This article reviews briefly the results of experiments in which selected genes have been transferred to the knee joints of healthy rabbits and rabbits with antigen-induced arthritis.
摘要
最近的技术进步使得基因能够转移至关节的滑膜衬里。这些技术不仅为治疗带来了新的机遇，还为研究滑膜炎以及健康和患病关节生物学的其他方面提供了宝贵的新工具。本文简要回顾了一些实验的结果，在这些实验中，特定基因已被转移至健康兔子和抗原诱导性关节炎兔子的膝关节。
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