急性肾衰竭：爱泼斯坦-巴尔病毒引起的传染性单核细胞增多症的罕见并发症。

Acute renal failure: unusual complication of Epstein-Barr virus-induced infectious mononucleosis.

作者信息

Lei P S, Lowichik A, Allen W, Mauch T J

机构信息

Department of Pediatrics, University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, UT 84132, USA.

出版信息

Clin Infect Dis. 2000 Dec;31(6):1519-24. doi: 10.1086/317497.

DOI:10.1086/317497

PMID:11096030

Abstract

A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.

摘要

一名17岁患青少年类风湿性关节炎的男孩，出现黄疸、意识模糊、溶血性贫血、血小板减少症以及继发于滴度确诊的急性爱泼斯坦-巴尔病毒（EBV）感染的急性肾衰竭。肾活检标本显示间质性肾炎，炎症浸润由细胞毒性/抑制性T细胞组成，且间质单核细胞核表达EBV编码的RNA-1（EBER-1）信使核糖核酸。甲基强的松龙治疗后病情迅速改善。