Kao C H, Hsieh J F, Tsai S C, Ho Y J, Chang H R
Department of Nuclear Medicine and Section of Nephrology, Taichung Veterans General Hospital, Taichung.
Am J Kidney Dis. 2000 Dec;36(6):1110-4. doi: 10.1053/ajkd.2000.19810.
It has been speculated that impaired salivary flow is common in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD). The aim of this study is to investigate the relation between oral manifestations and salivary function in patients with ESRD undergoing HD. Salivary function was measured by quantitative salivary scintigraphy in 60 patients with ESRD undergoing HD, as well as in 36 age- and sex-matched healthy controls for comparison. The 60 patients with ESRD undergoing HD were separated into two subgroups: group 1, 30 patients with oral manifestations, and group 2, 30 patients without oral manifestations. After an intravenous injection of 5 mCi of technetium 99m pertechnetate, sequential images at 1 minute per frame were acquired for 30 minutes. The 1- and 15-minute uptake ratios were calculated as the tracer uptakes in the four major salivary glands over the background regions of interest. Saliva excretion was stimulated by one 200-mg tablet of ascorbic acid administered orally 15 minutes post-tracer injection, then the maximal excretion ratios of the four major salivary glands were calculated. Our results show significantly poorer salivary function in patients with ESRD with oral manifestations compared with patients with ESRD without oral manifestations and healthy controls by means of objective and quantitative salivary scintigraphy.
据推测，在需要进行血液透析（HD）的终末期肾病（ESRD）患者中，唾液分泌受损情况很常见。本研究的目的是调查接受HD的ESRD患者的口腔表现与唾液功能之间的关系。通过定量唾液闪烁扫描法对60例接受HD的ESRD患者以及36例年龄和性别匹配的健康对照者进行唾液功能测量，以作比较。60例接受HD的ESRD患者被分为两个亚组：第1组，30例有口腔表现的患者；第2组，30例无口腔表现的患者。静脉注射5毫居里高锝[99mTc]酸钠后，以每分钟一帧的速度连续采集图像30分钟。计算1分钟和15分钟的摄取率，即四个主要唾液腺中的示踪剂摄取量与感兴趣的背景区域的比值。在注射示踪剂15分钟后口服一片200毫克的抗坏血酸刺激唾液分泌，然后计算四个主要唾液腺的最大分泌率。我们的结果显示，通过客观和定量的唾液闪烁扫描法，有口腔表现的ESRD患者的唾液功能明显比无口腔表现的ESRD患者和健康对照者差。
