Tremellen K P, Valbuena D, Landeras J, Ballesteros A, Martinez J, Mendoza S, Norman R J, Robertson S A, Simón C
Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, South Australia, Australia.
Hum Reprod. 2000 Dec;15(12):2653-8. doi: 10.1093/humrep/15.12.2653.
Intercourse during an IVF cycle has the potential to improve pregnancy rates since exposure to semen is reported to promote embryo development and implantation in animals. Conversely, coitus-induced uterine contractions or introduction of infection may have a detrimental effect. A multicentre prospective randomized control trial was conducted to determine if intercourse during the peri-transfer period of an IVF cycle has any influence on pregnancy success. Participants undergoing thawed embryo transfer (Australian centre) or fresh embryo transfers (Spanish centres) were randomized either to abstain or to engage in vaginal intercourse around the time of embryo transfer. The transfer of 1343 embryos during 478 cycles of IVF resulted in 107 pregnancies (22.4%), with 125 viable embryos remaining by 6-8 weeks gestation. There was no significant difference between the intercourse and abstain groups in relation to the pregnancy rate (23.6 and 21.2% respectively), but the proportion of transferred embryos that were viable at 6-8 weeks was significantly higher in women exposed to semen compared to those who abstained (11.01 versus 7.69 viable embryos per 100 transferred embryos, P = 0.036, odds ratio 1.48, 95% confidence interval 1.01-2.19). Hence exposure to semen around the time of embryo transfer increases the likelihood of successful early embryo implantation and development.
在体外受精（IVF）周期中进行性交有可能提高妊娠率，因为据报道，接触精液可促进动物胚胎发育和着床。相反，性交引起的子宫收缩或感染的引入可能会产生不利影响。进行了一项多中心前瞻性随机对照试验，以确定在IVF周期的胚胎移植前后进行性交是否会对妊娠成功产生任何影响。接受解冻胚胎移植的参与者（澳大利亚中心）或新鲜胚胎移植的参与者（西班牙中心）被随机分为在胚胎移植前后 abstain 或进行阴道性交两组。在478个IVF周期中移植了1343个胚胎，产生了107例妊娠（22.4%），到妊娠6-8周时仍有125个存活胚胎。性交组和 abstain 组的妊娠率没有显著差异（分别为23.6%和21.2%），但与 abstain 的女性相比，接触精液的女性在6-8周时存活的移植胚胎比例显著更高（每100个移植胚胎中存活胚胎数分别为11.01和7.69，P = 0.036，优势比1.48，95%置信区间1.01-2.19）。因此，在胚胎移植前后接触精液会增加早期胚胎成功着床和发育的可能性。
