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使用碘化钠(铊)闪烁体和位置灵敏光电倍增管开发用于乳腺闪烁成像的微型闪烁相机。

Development of a miniature scintillation camera using an NaI(Tl) scintillator and PSPMT for scintimammography.

作者信息

Kim J H, Choi Y, Joo K S, Sihn B S, Chong J W, Kim S E, Lee K H, Choe Y S, Kim B T

机构信息

Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea.

出版信息

Phys Med Biol. 2000 Nov;45(11):3481-8. doi: 10.1088/0031-9155/45/11/326.

DOI:10.1088/0031-9155/45/11/326
PMID:11098918
Abstract

We have developed a small scintillation camera dedicated to breast imaging and have evaluated the performance of the system. In order to increase the limited field of view (FOV) determined by the size of a position-sensitive photomultiplier tube (PSPMT), the imaging characteristics of a diverging hole collimator (DHC) were also investigated. The small scintillation camera system consists of an NaI(Tl) crystal (60 mm x 60 mm x 6 mm) coupled to a Hamamatsu R3941 PSPMT, a resistor chain circuit, preamplifiers, nuclear instrument modules, an analogue to digital converter and a PC for control and display. The intrinsic energy resolution of the system was 12.9% FWHM at 140 keV. The spatial resolution was measured using a line-slit mask and 99mTc point sources and was 3.1 mm FWHM. The intrinsic sensitivity of the system was approximately 162 counts/s kBq(-1). The DHC made it possible to image a larger FOV (75 x 75 mm2 at the surface of collimator) than a parallel-hole collimator (60 x 60 mm2). The system sensitivity obtained using the DHC gradually decreased with distance (3% at 1 cm, 6% at 2 cm and 9% at 3 cm). The results demonstrate that the system developed in this study could be utilized clinically to image malignant breast tumours. A DHC can be employed to expand the FOV of the system confined by the size of PSPMT with a modest compromise in the performance of the system.

摘要

我们开发了一款专门用于乳腺成像的小型闪烁相机,并对该系统的性能进行了评估。为了扩大由位置敏感光电倍增管(PSPMT)尺寸所决定的有限视野(FOV),我们还研究了发散孔准直器(DHC)的成像特性。小型闪烁相机系统由一块与滨松R3941型PSPMT耦合的碘化钠(铊)晶体(60毫米×60毫米×6毫米)、一个电阻链电路、前置放大器、核仪器模块、一个模数转换器以及一台用于控制和显示的个人计算机组成。该系统在140keV时的固有能量分辨率为半高宽(FWHM)的12.9%。使用线缝掩模和99mTc点源测量的空间分辨率为半高宽3.1毫米。该系统的固有灵敏度约为162计数/秒·kBq⁻¹。与平行孔准直器(60×60毫米²)相比,DHC能够对更大的视野(准直器表面为75×75毫米²)进行成像。使用DHC获得的系统灵敏度随着距离逐渐降低(1厘米处为3%,2厘米处为6%,3厘米处为9%)。结果表明,本研究中开发的系统可用于临床乳腺恶性肿瘤成像。DHC可用于扩大受PSPMT尺寸限制的系统视野,同时在系统性能上有适度的折衷。

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