Freeman M
MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature. 2000 Nov 16;408(6810):313-9. doi: 10.1038/35042500.
The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.
在动物发育过程中，调节细胞命运的细胞间通讯必须得到精确控制，以避免出现危险的错误。这是如何实现的呢？最近的研究突出了正负反馈回路在发育信号动态调节中的重要性。这些反馈相互作用能够赋予细胞间信号精确性、稳健性和多功能性。反馈失灵会导致疾病。
