Tyler Melinda J, Cameron David A
Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA.
Vision Res. 2007 Feb;47(4):501-11. doi: 10.1016/j.visres.2006.08.025. Epub 2006 Oct 10.
A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The model successfully simulated quantitative features of in vivo regenerated patterns, indicating that regenerating retina has access to and utilizes patterning mechanisms that are operational during normal growth. The atypical patterns of regenerated retina could arise in part from regenerative progenitors that, compared to normal growth progenitors, are less responsive to the feedback patterning signals.
在生长中的鱼类视网膜中，细胞模式形成的一个主要机制是由分化细胞产生的负反馈信号控制细胞命运的获得。我们测试了这种模式形成机制的计算模型模拟再生金鱼视网膜中细胞模式的能力。该模型成功地模拟了体内再生模式的定量特征，表明再生视网膜能够利用在正常生长过程中起作用的模式形成机制。再生视网膜的非典型模式可能部分源于再生祖细胞，与正常生长祖细胞相比，这些祖细胞对反馈模式信号的反应较弱。
