Araki Y, Fujiyama Y, Andoh A, Koyama S, Kanauchi O, Bamba T
Dept. of Internal Medicine, Nagahama Red Cross Hospital, Japan.
Scand J Gastroenterol. 2000 Oct;35(10):1060-7. doi: 10.1080/003655200451180.
Recent studies have suggested that dietary fiber exerts a therapeutic effect on IBD patients. The aim of this study was to evaluate the effects of a dietary combination of germinated barley foodstuff (GBF), derived from the aleurone and scutellum fraction of germinated barley, plus Clostridium butyricum against dextran sulfate sodium (DSS)-induced experimental colitis in rats.
Sprague-Dawley rats were fed a 3% DSS diet containing GBF only, GBF plus C. butyricum, cellulose only (control) or cellulose plus C. butyricum for 8 days. The mucosal damage (macroscopic and microscopic inflammation) and fecal short-chain fatty acid (SCFA) levels were then determined.
The combination of GBF plus C. butyricum most effectively prevented bloody diarrhea and mucosal damage. The GBF-only diet also showed some preventive effects. With respect to fecal SCFAs, the combination of GBF plus C. butyricum most effectively increased the fecal SCFA level.
The dietary combination of GBF plus C. butyricum most effectively suppressed DSS-induced experimental colitis in rats. These effects may be closely associated with its high activity to increase SCFA levels in the gut lumen. The potential clinical efficacy of GBF in IBD patients is also discussed.
近期研究表明膳食纤维对炎症性肠病（IBD）患者具有治疗作用。本研究旨在评估源自发芽大麦糊粉层和盾片部分的发芽大麦食品（GBF）与丁酸梭菌的饮食组合对葡聚糖硫酸钠（DSS）诱导的大鼠实验性结肠炎的影响。
将斯普拉格-道利大鼠分别喂食仅含GBF的3% DSS饮食、GBF加丁酸梭菌、仅含纤维素（对照）或纤维素加丁酸梭菌的饮食，持续8天。然后测定黏膜损伤（宏观和微观炎症）以及粪便短链脂肪酸（SCFA）水平。
GBF加丁酸梭菌的组合最有效地预防了血性腹泻和黏膜损伤。仅含GBF的饮食也显示出一些预防作用。关于粪便SCFA，GBF加丁酸梭菌的组合最有效地提高了粪便SCFA水平。
GBF加丁酸梭菌的饮食组合最有效地抑制了DSS诱导的大鼠实验性结肠炎。这些作用可能与其提高肠腔内SCFA水平的高活性密切相关。还讨论了GBF在IBD患者中的潜在临床疗效。
