Kanauchi O, Nakamura T, Agata K, Mitsuyama K, Iwanaga T
Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma, Japan.
J Gastroenterol. 1998 Apr;33(2):179-88. doi: 10.1007/s005350050067.
Germinated barley foodstuff (GBF), derived from the aleurone and scutellum fractions of germinated barley, is rich in glutamine and low-lignified hemicellulose, and increases mucosal protein, RNA, and DNA content in the intestine when fed to normal rats. The aim of this study was to evaluate the effects of feeding GBF or germinated gramineous seeds on experimental ulcerative colitis. Sprague-Dawley rats that received 3% dextran sulfate sodium in their diets were used as an experimental colitis model. The effects of sulfasalazine, a drug used to treat inflammatory bowel disease, were compared with those of GBF. After rats had consumed diets containing GBF or various aleurone and scutellum fractions, mucosal damage; the content of mucosal protein, RNA, and DNA in the colo-rectum; and serum interleukin-8 and alpha1-acid glycoprotein levels were assessed. GBF and germinated seeds more effectively prevented bloody diarrhea and mucosal damage in colitis compared with controls and rats receiving sulfasalazine, but non-germinated samples did not have a protective effect. GBF increased mucosal protein and RNA content in the colitis model. The consumption of GBF appears to prevent inflammation in a colitis model, and its effect seems to be related to the germination process. GBF and germinated seeds have the potential to serve as nutritional therapy for ulcerative colitis.
发芽大麦食品（GBF）源自发芽大麦的糊粉层和盾片部分，富含谷氨酰胺和低木质化半纤维素，喂食正常大鼠时可增加肠道黏膜蛋白、RNA和DNA含量。本研究的目的是评估喂食GBF或发芽禾本科种子对实验性溃疡性结肠炎的影响。将在饮食中摄入3%硫酸葡聚糖钠的斯普拉格-道利大鼠用作实验性结肠炎模型。将用于治疗炎症性肠病的药物柳氮磺胺吡啶的效果与GBF的效果进行比较。在大鼠食用含有GBF或各种糊粉层和盾片部分的饮食后，评估黏膜损伤、结直肠黏膜蛋白、RNA和DNA含量以及血清白细胞介素-8和α1-酸性糖蛋白水平。与对照组和接受柳氮磺胺吡啶的大鼠相比，GBF和发芽种子能更有效地预防结肠炎中的血性腹泻和黏膜损伤，但未发芽的样品没有保护作用。GBF增加了结肠炎模型中的黏膜蛋白和RNA含量。食用GBF似乎可以预防结肠炎模型中的炎症，其作用似乎与发芽过程有关。GBF和发芽种子有潜力作为溃疡性结肠炎的营养疗法。
