Kitano M, Sakaguchi K, Miyashita M, Mouri H, Senoh T, Nishimura M, Ohta T, Fujio K, Shimomura H, Tsuji T
First Department of Internal Medicine, Okayama University Medical School, Japan.
Hepatogastroenterology. 2000 Sep-Oct;47(35):1340-2.
BACKGROUND/AIMS: We investigated the prevalence of hepatitis G virus infection among inhabitants of a hepatitis C virus endemic area.
Two hundred and eighty-eight inhabitants, who underwent medical examinations for health screening, were enrolled in this epidemiological study. HGV RNA and HCV RNA were detected by polymerase chain reaction. We also examined anti-HGV envelope protein (E2) antibodies in all serum samples.
In these 288 inhabitants, we found anti-HCV antibodies (HCV-Ab) and HCV RNA in 28.5% and 17.4%, respectively. HGV RNA and anti-HGV E2 were detected in 9 (3.1%) and 16 (5.5%), respectively. One patient was positive for both HGV RNA and anti-HGV E2. The exposure rate, expressed as the percentage of people with HGV RNA and/or anti-HGV E2, was 8.3%, which was significantly lower than the incidence of positive HCV-Ab. Of the 24 patients with HGV RNA and/or anti-HGV E2, 15 (62.5%) were positive for HCV-Ab, of those HCV RNA was detected in 9 (37.5%). Further, we found a higher prevalence of HGV exposure in patients with HCV-Ab than in those without (8.3% vs. 4.4%).
HGV infection was not identical to the epidemic hepatitis C virus infection among inhabitants of this town, suggesting that hepatitis C virus might be less infectious than hepatitis C virus.
背景/目的：我们调查了丙型肝炎病毒流行地区居民中庚型肝炎病毒感染的患病率。
本流行病学研究纳入了288名接受健康筛查医学检查的居民。通过聚合酶链反应检测庚型肝炎病毒RNA（HGV RNA）和丙型肝炎病毒RNA（HCV RNA）。我们还检测了所有血清样本中的抗庚型肝炎病毒包膜蛋白（E2）抗体。
在这288名居民中，我们分别在28.5%和17.4%的居民中发现了抗丙型肝炎病毒抗体（HCV-Ab）和丙型肝炎病毒RNA。分别在9名（3.1%）和16名（5.5%）居民中检测到了庚型肝炎病毒RNA和抗庚型肝炎病毒E2抗体。1名患者的庚型肝炎病毒RNA和抗庚型肝炎病毒E2抗体均为阳性。以庚型肝炎病毒RNA和/或抗庚型肝炎病毒E2抗体阳性者的百分比表示的暴露率为8.3%，显著低于抗丙型肝炎病毒抗体阳性的发生率。在24名庚型肝炎病毒RNA和/或抗庚型肝炎病毒E2抗体阳性的患者中，15名（62.5%）抗丙型肝炎病毒抗体阳性，其中9名（37.5%）检测到丙型肝炎病毒RNA。此外，我们发现抗丙型肝炎病毒抗体阳性患者的庚型肝炎病毒暴露患病率高于无抗丙型肝炎病毒抗体者（8.3%对4.4%）。
在该镇居民中，庚型肝炎病毒感染与丙型肝炎病毒流行感染不同，提示庚型肝炎病毒的传染性可能低于丙型肝炎病毒。
