Thompson A K, Juniper E, Meltzer E O
US Medical Affairs, Aventis Pharmaceuticals Inc, Kansas City, Missouri 64137, USA.
Ann Allergy Asthma Immunol. 2000 Nov;85(5):338-47; quiz 347-8. doi: 10.1016/S1081-1206(10)62543-4.
Reading this article will familiarize the practitioner with ongoing efforts to measure the effects of allergic rhinitis symptoms and its treatments on the health-related quality of life (HRQOL) of patients. The reader will learn about instruments used to collect HRQOL data, results of studies showing the burden of illness and the effects of treatments on HRQOL, and efforts to interpret the clinical relevance of changes in HRQOL status.
Information was gleaned from articles listed in MEDLINE regarding HRQOL in allergic rhinitis between 1966 and 2000 (English language only), and from the personal experiences of the authors.
Questionnaire validation studies and representative controlled trials employing measures to assess the effects of allergic rhinitis symptoms and its treatments on HRQOL are described. RESULTS FROM THIS REVIEW: Allergic rhinitis symptoms can have detrimental effects on the physical, psychologic, and social aspects of patients' lives. Clinical trial data suggest a variety of pharmacologic therapies can significantly improve HRQOL in patients with allergic rhinitis. Validated questionnaires are now available that can easily be used in clinical practice to measure the effects of interventions on HRQOL for individual patients.
Evaluating the effects of interventions on HRQOL may be particularly important in a non-life-threatening condition such as rhinitis. Health-related quality of life measures can be used to indicate the risk/benefit and the cost/benefit ratios of competing treatment options. Clinicians and policy makers are already using HRQOL data to evaluate results of medical interventions to guide patient management and reimbursement decisions.
阅读本文将使从业者熟悉目前为衡量变应性鼻炎症状及其治疗对患者健康相关生活质量（HRQOL）的影响所做的努力。读者将了解用于收集HRQOL数据的工具、显示疾病负担及治疗对HRQOL影响的研究结果，以及解读HRQOL状态变化临床相关性的努力。
信息收集自1966年至2000年MEDLINE中列出的关于变应性鼻炎HRQOL的文章（仅限英文）以及作者的个人经验。
描述了采用评估变应性鼻炎症状及其治疗对HRQOL影响的措施的问卷验证研究和代表性对照试验。本综述结果：变应性鼻炎症状可对患者生活的身体、心理和社会方面产生不利影响。临床试验数据表明，多种药物疗法可显著改善变应性鼻炎患者的HRQOL。现已可获得经过验证的问卷，可轻松用于临床实践，以衡量干预措施对个体患者HRQOL的影响。
在鼻炎这种非危及生命的疾病中，评估干预措施对HRQOL的影响可能尤为重要。健康相关生活质量测量可用于表明相互竞争的治疗方案的风险/效益和成本/效益比。临床医生和政策制定者已经在使用HRQOL数据来评估医疗干预的结果，以指导患者管理和报销决策。
