视网膜昼夜节律钟的相位转移：光照和多巴胺诱导xPer2 mRNA表达
Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine.
作者信息
Steenhard B M, Besharse J C
机构信息
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
出版信息
J Neurosci. 2000 Dec 1;20(23):8572-7. doi: 10.1523/JNEUROSCI.20-23-08572.2000.
Abstract
A circadian clock is located in the retinal photoreceptors of the African clawed frog Xenopus laevis. These photoreceptor clocks are thought to govern a wide variety of output rhythms, including melatonin release and gene expression. Both light and dopamine phase shift the retinal clock in a phase-dependent manner. Two homologs of the Drosophila period gene have been cloned in Xenopus, and one of these (xPer2) is acutely regulated by light. Light and dopamine induce xPer2 mRNA in a similar manner. In addition, the increase of xPer2 mRNA in response to light and dopamine is the same at all times of day tested. In contrast, xPer1 mRNA exhibits circadian oscillations but is relatively insensitive to phase-shifting treatments of light or dopamine. Our data suggest that xPer2 functions as the molecular link between the light/dark cycle and the circadian clock.
摘要
生物钟位于非洲爪蟾（非洲爪蟾）的视网膜光感受器中。这些光感受器生物钟被认为控制着各种各样的输出节律，包括褪黑素释放和基因表达。光和多巴胺都以相位依赖的方式使视网膜生物钟发生相位移动。在爪蟾中已克隆出果蝇周期基因的两个同源物，其中一个（xPer2）受光的急性调节。光和多巴胺以相似的方式诱导xPer2 mRNA。此外，在一天中所有测试时间，xPer2 mRNA对光和多巴胺的反应增加是相同的。相比之下，xPer1 mRNA表现出昼夜节律振荡，但对光或多巴胺的相位移动处理相对不敏感。我们的数据表明，xPer2作为光/暗周期与生物钟之间的分子联系发挥作用。
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本文引用的文献
1
Differential regulation of two period genes in the Xenopus eye.非洲爪蟾眼睛中两个周期基因的差异调控。
Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):52-64. doi: 10.1016/s0169-328x(00)00177-7.
2
Molecular analysis of avian circadian clock genes.
Brain Res Mol Brain Res. 2000 May 31;78(1-2):207-15. doi: 10.1016/s0169-328x(00)00091-7.
3
GFP fluorescence reports Period 1 circadian gene regulation in the mammalian biological clock.绿色荧光蛋白（GFP）荧光报告了哺乳动物生物钟中周期1昼夜节律基因的调控情况。
Neuroreport. 2000 May 15;11(7):1479-82.
4
Interacting molecular loops in the mammalian circadian clock.哺乳动物生物钟中的相互作用分子环
Science. 2000 May 12;288(5468):1013-9. doi: 10.1126/science.288.5468.1013.
5
Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms.对小鼠视交叉上核中生物钟蛋白的分析表明，昼夜节律机制和重置机制存在系统发育差异。
Neuron. 2000 Feb;25(2):437-47. doi: 10.1016/s0896-6273(00)80906-x.
6
Structure and function of dopamine receptors.多巴胺受体的结构与功能。
Neurosci Biobehav Rev. 2000 Jan;24(1):125-32. doi: 10.1016/s0149-7634(99)00063-9.
7
Rapid down-regulation of mammalian period genes during behavioral resetting of the circadian clock.在生物钟行为重置过程中哺乳动物周期基因的快速下调。
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15211-6. doi: 10.1073/pnas.96.26.15211.
8
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.CRY1和CRY2在哺乳动物生物钟中的非光依赖作用。
Science. 1999 Oct 22;286(5440):768-71. doi: 10.1126/science.286.5440.768.
9
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.mCRY1和mCRY2是生物钟反馈回路负向分支的重要组成部分。
Cell. 1999 Jul 23;98(2):193-205. doi: 10.1016/s0092-8674(00)81014-4.
10
The mPer2 gene encodes a functional component of the mammalian circadian clock.mPer2基因编码哺乳动物生物钟的一个功能组件。
Nature. 1999 Jul 8;400(6740):169-73. doi: 10.1038/22118.
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