Clark R E, Zola S M, Squire L R
Veterans Affairs Medical Center, San Diego, California 92161, USA.
J Neurosci. 2000 Dec 1;20(23):8853-60. doi: 10.1523/JNEUROSCI.20-23-08853.2000.
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory.
对海马体有射频或鹅膏蕈氨酸损伤的大鼠以及穹窿有射频损伤的大鼠进行了视觉配对比较任务（VPC）测试，这是一种识别记忆测试。在从10秒到24小时的五个不同延迟间隔评估记忆。所有手术组在较短延迟（10秒和1分钟）时表现正常。在较长延迟期间，两组海马体损伤的大鼠表现受损。穹窿损伤的大鼠在VPC任务中表现良好，但在空间任务（自发交替）中受损。结果表明，海马体对正常识别记忆至关重要。此外，穹窿损伤不一定会模拟对海马体组织直接损伤的效果。在海马体对识别记忆的贡献背景下讨论了这些发现。
