海马体损伤后大鼠的识别记忆受损。
Impaired recognition memory in rats after damage to the hippocampus.
作者信息
Clark R E, Zola S M, Squire L R
机构信息
Veterans Affairs Medical Center, San Diego, California 92161, USA.
出版信息
J Neurosci. 2000 Dec 1;20(23):8853-60. doi: 10.1523/JNEUROSCI.20-23-08853.2000.
Abstract
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory.
摘要
对海马体有射频或鹅膏蕈氨酸损伤的大鼠以及穹窿有射频损伤的大鼠进行了视觉配对比较任务（VPC）测试，这是一种识别记忆测试。在从10秒到24小时的五个不同延迟间隔评估记忆。所有手术组在较短延迟（10秒和1分钟）时表现正常。在较长延迟期间，两组海马体损伤的大鼠表现受损。穹窿损伤的大鼠在VPC任务中表现良好，但在空间任务（自发交替）中受损。结果表明，海马体对正常识别记忆至关重要。此外，穹窿损伤不一定会模拟对海马体组织直接损伤的效果。在海马体对识别记忆的贡献背景下讨论了这些发现。
相似文献
1
Impaired recognition memory in rats after damage to the hippocampus.海马体损伤后大鼠的识别记忆受损。
J Neurosci. 2000 Dec 1;20(23):8853-60. doi: 10.1523/JNEUROSCI.20-23-08853.2000.
2
The hippocampal/parahippocampal regions and recognition memory: insights from visual paired comparison versus object-delayed nonmatching in monkeys.海马体/海马旁回区域与识别记忆：来自猴子视觉配对比较和物体延迟非匹配实验的见解
J Neurosci. 2004 Feb 25;24(8):2013-26. doi: 10.1523/JNEUROSCI.3763-03.2004.
3
A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex lesions on spatial reference and working memory in rats: short versus long postsurgical recovery period.穹窿-海马伞、海马或内嗅皮质损伤对大鼠空间参考记忆和工作记忆影响的比较：术后短期与长期恢复期
Neurobiol Learn Mem. 2002 Jan;77(1):1-16. doi: 10.1006/nlme.2000.3998.
4
Impaired recognition of the goal location during spatial navigation in rats with hippocampal lesions.海马体损伤大鼠在空间导航过程中对目标位置的识别受损。
J Neurosci. 2001 Jun 15;21(12):4505-13. doi: 10.1523/JNEUROSCI.21-12-04505.2001.
5
Neurotoxic hippocampal lesions have no effect on odor span and little effect on odor recognition memory but produce significant impairments on spatial span, recognition, and alternation.神经毒性海马损伤对气味广度没有影响，对气味识别记忆影响较小，但对空间广度、识别和交替产生显著损害。
J Neurosci. 2000 Apr 15;20(8):2964-77. doi: 10.1523/JNEUROSCI.20-08-02964.2000.
6
Memory for spatial location and object-place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex.海马结构、海马旁区域TH/TF和内嗅皮质对空间位置记忆和物体-位置关联的处理方式有所不同。
Hippocampus. 2008;18(1):64-80. doi: 10.1002/hipo.20369.
7
Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task.海马体受损的大鼠在延迟非匹配样本任务中表现受损。
Hippocampus. 2001;11(2):176-86. doi: 10.1002/hipo.1035.
8
Fimbria-fornix vs selective hippocampal lesions in rats: effects on locomotor activity and spatial learning and memory.大鼠穹窿海马伞与选择性海马损伤：对运动活动及空间学习与记忆的影响
Neurobiol Learn Mem. 1998 Jan;69(1):22-45. doi: 10.1006/nlme.1997.3807.
9
Neonatal aspiration lesions of the hippocampal formation impair visual recognition memory when assessed by paired-comparison task but not by delayed nonmatching-to-sample task.当通过配对比较任务评估时，海马结构的新生儿吸入性损伤会损害视觉识别记忆，但通过延迟非匹配样本任务评估时则不会。
Hippocampus. 1999;9(6):609-16. doi: 10.1002/(SICI)1098-1063(1999)9:6<609::AID-HIPO1>3.0.CO;2-A.
10
Dissociations in the effect of delay on object recognition: evidence for an associative model of recognition memory.延迟对物体识别影响的分离现象：识别记忆关联模型的证据
J Exp Psychol Anim Learn Cogn. 2014 Jan;40(1):106-15. doi: 10.1037/xan0000003.
引用本文的文献
1
Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.在Tg2576 APP/Aβ小鼠模型中，对N端tau蛋白进行急性靶向作用可通过减轻晚年的认知障碍、脑Aβ淀粉样变性、突触重塑和小胶质细胞增生，产生长期有益影响。
Acta Neuropathol Commun. 2025 May 29;13(1):121. doi: 10.1186/s40478-025-02022-y.
2
Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats.成年雄性斯普拉格-道利大鼠全脑质子常规剂量率或超高剂量率（FLASH）照射的影响。
Sci Rep. 2025 Mar 27;15(1):10602. doi: 10.1038/s41598-025-94534-9.
3
Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice.少突胶质细胞自噬功能障碍导致老年小鼠出现髓鞘形态缺陷、神经元凋亡和认知衰退。
Glia. 2025 Jul;73(7):1383-1397. doi: 10.1002/glia.70012. Epub 2025 Mar 19.
4
Disruption of Extracellular Signal-Regulated Kinase Partially Mediates Neonatal Isoflurane Anesthesia-Induced Changes in Dendritic Spines and Cognitive Function in Juvenile Mice.细胞外信号调节激酶的破坏部分介导新生小鼠异氟烷麻醉诱导的幼鼠树突棘和认知功能变化。
Int J Mol Sci. 2025 Jan 24;26(3):981. doi: 10.3390/ijms26030981.
5
Org24598, a Selective Glycine Transporter 1 (GlyT1) Inhibitor, Reverses Object Recognition and Spatial Memory Impairments Following Binge-like Ethanol Exposure in Rats.Org24598，一种选择性甘氨酸转运体1（GlyT1）抑制剂，可逆转大鼠暴饮样乙醇暴露后的物体识别和空间记忆损伤。
Molecules. 2024 Dec 20;29(24):6017. doi: 10.3390/molecules29246017.
6
VNS paired with training enhances recognition memory: mechanistic insights from proteomic analysis of the hippocampal synapse.迷走神经刺激联合训练可增强识别记忆：来自海马体突触蛋白质组分析的机制见解
Front Mol Neurosci. 2024 Dec 16;17:1452327. doi: 10.3389/fnmol.2024.1452327. eCollection 2024.
7
FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application.FLASH放疗：其临床应用的益处、机制及障碍
Int J Mol Sci. 2024 Nov 21;25(23):12506. doi: 10.3390/ijms252312506.
8
Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and Associated Spatial Memory Impairments in Rats.保护神经元完整性：揭示核因子κB在穿心莲内酯对大鼠氯化铝诱导的神经毒性及相关空间记忆损伤的神经保护作用中的可能作用。
Cent Nerv Syst Agents Med Chem. 2025;25(2):157-168. doi: 10.2174/0118715249284798240509052913.
9
The small conductance Ca-activated K channel activator GW542573X impairs hippocampal memory in C57BL/6J mice.小电导钙激活钾通道激活剂 GW542573X 损害 C57BL/6J 小鼠的海马记忆。
Neuropharmacology. 2024 Jul 1;252:109960. doi: 10.1016/j.neuropharm.2024.109960. Epub 2024 Apr 16.
10
Neuroprotective mechanism of trans,trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer's pathology.法尼醇的神经保护机制在脑室注射 STZ 诱导的阿尔茨海默病大鼠模型中的作用。
Inflammopharmacology. 2024 Apr;32(2):1545-1573. doi: 10.1007/s10787-023-01413-8. Epub 2024 Feb 3.
本文引用的文献
1
Loss of recent memory after bilateral hippocampal lesions.双侧海马体损伤后近期记忆丧失。
J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11-21. doi: 10.1136/jnnp.20.1.11.
2
Hippocampus and contextual fear conditioning: recent controversies and advances.海马体与情境恐惧条件反射：近期的争议与进展
Hippocampus. 2001;11(1):8-17. doi: 10.1002/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7.
3
The neurophysiology of memory.记忆的神经生理学
Ann N Y Acad Sci. 2000 Jun;911:175-91. doi: 10.1111/j.1749-6632.2000.tb06726.x.
4
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice.富集诱导CA1区NMDAR1基因敲除小鼠的结构变化并使其从非空间记忆缺陷中恢复。
Nat Neurosci. 2000 Mar;3(3):238-44. doi: 10.1038/72945.
5
Neonatal aspiration lesions of the hippocampal formation impair visual recognition memory when assessed by paired-comparison task but not by delayed nonmatching-to-sample task.当通过配对比较任务评估时，海马结构的新生儿吸入性损伤会损害视觉识别记忆，但通过延迟非匹配样本任务评估时则不会。
Hippocampus. 1999;9(6):609-16. doi: 10.1002/(SICI)1098-1063(1999)9:6<609::AID-HIPO1>3.0.CO;2-A.
6
Long-term effects of neonatal damage to the hippocampal formation and amygdaloid complex on object discrimination and object recognition in rhesus monkeys (Macaca mulatta).新生期海马结构和杏仁复合体损伤对恒河猴（猕猴）物体辨别和物体识别的长期影响。
Behav Neurosci. 1999 Dec;113(6):1127-51. doi: 10.1037//0735-7044.113.6.1127.
7
Impaired recognition memory in monkeys after damage limited to the hippocampal region.仅限于海马区受损后猴子的识别记忆受损。
J Neurosci. 2000 Jan 1;20(1):451-63. doi: 10.1523/JNEUROSCI.20-01-00451.2000.
8
Hippocampal formation lesions produce memory impairment in the rhesus monkey.海马结构损伤会导致恒河猴出现记忆障碍。
Hippocampus. 1999;9(5):562-74. doi: 10.1002/(SICI)1098-1063(1999)9:5<562::AID-HIPO10>3.0.CO;2-X.
9
Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition.扩展识别的自发偏好测试：物体位置和物体背景识别的证据。
Behav Brain Res. 1999 Mar;99(2):191-200. doi: 10.1016/s0166-4328(98)00079-5.
10
Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus.杏仁核和海马体兴奋性毒性损伤的猴子的物体识别与位置记忆
J Neurosci. 1998 Aug 15;18(16):6568-82. doi: 10.1523/JNEUROSCI.18-16-06568.1998.
Zotero 插件