Cheng C L, Koo M W
Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, China.
Life Sci. 2000 Oct 13;67(21):2647-53. doi: 10.1016/s0024-3205(00)00848-1.
Centella asiatica is a herbal medicine widely used in China and India for wound healing. The aim of this study was to examine its effects on the prevention of ethanol induced gastric lesions in rats. Gastric transmucosal potential difference (PD) was reduced by the application of 50% ethanol in the gastric ex-vivo chamber model and Centella extract (CE) accelerated its recovery. Oral administration of CE (0.05 g/kg, 0.25 g/kg and 0.50 g/kg) before ethanol administration significantly inhibited gastric lesions formation (58% to 82% reduction) and decreased mucosal myeloperoxidase (MPO) activity in a dose dependent manner. These results suggested that CE prevented ethanol induced gastric mucosal lesions by strengthening the mucosal barrier and reducing the damaging effects of free radicals.
积雪草是一种在中国和印度广泛用于伤口愈合的草药。本研究的目的是考察其对预防大鼠乙醇诱导的胃损伤的作用。在离体胃腔模型中，应用50%乙醇可降低胃黏膜跨膜电位差（PD），而积雪草提取物（CE）可加速其恢复。乙醇给药前口服CE（0.05 g/kg、0.25 g/kg和0.50 g/kg）可显著抑制胃损伤形成（减少58%至82%），并以剂量依赖性方式降低黏膜髓过氧化物酶（MPO）活性。这些结果表明，CE通过增强黏膜屏障和减少自由基的损伤作用来预防乙醇诱导的胃黏膜损伤。
