PA结构域：一种蛋白酶相关结构域。
The PA domain: a protease-associated domain.
作者信息
Mahon P, Bateman A
机构信息
Department of Biochemistry, University of Cambridge, United Kingdom.
出版信息
Protein Sci. 2000 Oct;9(10):1930-4. doi: 10.1110/ps.9.10.1930.
Abstract
We have identified a similarity between the apical domain of the human transferrin receptor and several other protein families. This domain is found associated with two different families of peptidases. Therefore, we term it the PA domain for protease-associated domain. The PA domain is found inserted within a loop of the peptidase domain of family M8/M33 zinc peptidases. The PA domain is also found in a vacuolar sorting receptor and a ring finger protein of unknown function that may be a cell surface receptor. The PA domain may mediate substrate determination of peptidases or form protein-protein interactions.
摘要
我们已经确定了人类转铁蛋白受体的顶端结构域与其他几个蛋白质家族之间的相似性。该结构域与两个不同的肽酶家族相关。因此，我们将其命名为蛋白酶相关结构域（PA结构域）。PA结构域被发现插入到M8/M33锌肽酶家族肽酶结构域的一个环内。PA结构域也存在于液泡分选受体和一种功能未知的可能是细胞表面受体的环指蛋白中。PA结构域可能介导肽酶的底物识别或形成蛋白质-蛋白质相互作用。
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