Gencay M, Koskiniemi M, Ammälä P, Fellman V, Närvänen A, Wahlström T, Vaheri A, Puolakkainen M
Department of Virology, Haartman Institute, University of Helsinki, Finland.
APMIS. 2000 Sep;108(9):584-8. doi: 10.1034/j.1600-0463.2000.d01-101.x.
The cause of stillbirth and preterm delivery is often unknown. We studied the prevalence of Chlamydia trachomatis antibodies in mothers with stillbirth and preterm labor. Serum specimens from 72 mothers with stillbirth after the 21st gestational week, and from 48 mothers with preterm delivery between gestational weeks 23 and 29, both from the greater Helsinki area, and cord blood from 96 consecutive liveborn deliveries at the Department of Obstetrics and Gynecology, the University of Helsinki, were studied for antibodies to C. trachomatis immunotypes CJHI, GFK and BED by microimmunofluorescence test. The prevalence of C. trachomatis antibodies was highest, 33.3%, in mothers with stillbirth, 18.8% in mothers with preterm delivery, and 10.4% in cord blood. The IgM seropositivity rate was high among mothers with preterm delivery (8.3%). We conclude that C. trachomatis IgG antibodies are frequently detected in sera from mothers with stillbirth, suggesting past infection, while mothers with preterm delivery often have serum IgM antibodies, suggesting of acute infection.
死产和早产的原因通常不明。我们研究了死产和早产母亲中沙眼衣原体抗体的流行情况。对来自大赫尔辛基地区的72例妊娠21周后死产母亲、48例妊娠23至29周早产母亲的血清标本，以及赫尔辛基大学妇产科连续96例活产分娩的脐带血，采用微量免疫荧光试验检测沙眼衣原体免疫型CJHI、GFK和BED的抗体。沙眼衣原体抗体的流行率在死产母亲中最高，为33.3%，早产母亲中为18.8%，脐带血中为10.4%。早产母亲中IgM血清阳性率较高（8.3%）。我们得出结论，死产母亲血清中经常检测到沙眼衣原体IgG抗体，提示既往感染，而早产母亲血清中常存在IgM抗体，提示急性感染。
