Haspel M V, Rapp F
Science. 1975 Feb 7;187(4175):450-1. doi: 10.1126/science.1111114.
Mutagenization of measles virus with proflavine produced a temperature-sensitive mutant capable of inducing hydrocephalus following intracranial inoculation of newborn hamsters. Hydrocephalus was not produced by the parental strain or by other measles virus mutants. Thus, mutants can be the causative agents of disease not associated with the parental strain. The results dictate caution in the use and distribution of experimentally induced virus variants.
用原黄素对麻疹病毒进行诱变产生了一种温度敏感突变体，该突变体在新生仓鼠颅内接种后能够诱发脑积水。亲代毒株或其他麻疹病毒突变体不会产生脑积水。因此，突变体可能是与亲代毒株无关的疾病病原体。这些结果表明在使用和传播实验诱导的病毒变体时需谨慎。
