Hernandez-Richter T, Schardey H M, Löhlein F, Heiss M M, Redondo-Müller M, Hammer C, Schildberg F W
Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig Maximilians-Universität, München, Germany.
Eur J Vasc Endovasc Surg. 2000 Nov;20(5):413-8. doi: 10.1053/ejvs.2000.1199.
to evaluate the role of Triclosan (Irgasan(R)) in the prevention of prosthetic graft infection.
fifty-one pigs were assigned randomly to six groups. Group I (graft) and II (graft and Triclosan) were control groups. Groups III (graft) and IV (grafts and Triclosan) were contaminated with 2 x 10(7)CFU/ml S. aureus. Groups V (graft) and VI (graft and Triclosan) were intraoperatively contaminated with 2 x 10(7)CFU/ml S. aureus and reoperated on after 7 days. Remaining animals were sacrificed on day 28. The end point of the investigation was vascular graft infection, defined as the bacteriological and/or histological proof of infection. Results in both control groups no vascular graft infections were detected in Groups I and II. All of the group III animals presented but none of the group IV developed a graft infection (p <0.02). All of the group V animals presented and 10 of 12 animals developed a graft infection.
in this animal model Triclosan bonding appears effective in preventing prosthetic graft infection. However, the in situ replacement of Triclosan-protected grafts was not successful in the treatment of graft infection.
评估三氯生（玉洁新）在预防人工血管移植物感染中的作用。
将51头猪随机分为6组。I组（移植物）和II组（移植物与三氯生）为对照组。III组（移植物）和IV组（移植物与三氯生）用2×10⁷CFU/ml金黄色葡萄球菌污染。V组（移植物）和VI组（移植物与三氯生）在术中用2×10⁷CFU/ml金黄色葡萄球菌污染，并在7天后再次手术。其余动物在第28天处死。研究终点为血管移植物感染，定义为感染的细菌学和/或组织学证据。结果在两个对照组中，I组和II组均未检测到血管移植物感染。III组所有动物均出现感染，但IV组无动物发生移植物感染（p<0.02）。V组所有动物均出现感染，12只动物中有10只发生移植物感染。
在该动物模型中，三氯生结合似乎对预防人工血管移植物感染有效。然而，原位更换三氯生保护的移植物在治疗移植物感染方面并不成功。
