Papalambros Efstathios, Sigala Fragiska, Georgopoulos Sotiris, Menekakos Charalambos, Giatromanolaki Alexandra, Bastounis Elias, Sivridis Efthymios
First Department of Surgery, University of Athens, 27 Chremonidou Street, 11633 Pagrati, Athens, Greece.
Int J Mol Med. 2003 Dec;12(6):965-8.
Our purpose was to investigate the expression of matrix metalloproteinase (MMP)-2 and -9 in all types of abdominal aortic aneurysms (AAA): symptomatic, asymptomatic, and ruptured. MMP-2 and -9 activity was investigated in surgical samples from the arterior wall of 46 AAA, using a standard immunohistochemical technique. The MMP-9 activity was significantly higher in large AAA (>6 cm), but there was no relation between AAA size and MMP-2 activity. Neither MMP-2 nor MMP-9 were related with AAA rupture, other complications or symptoms. The MMP-9 activity in AAA is a determinant of the aneurysm size, but it is not related to clinical manifestations.
我们的目的是研究基质金属蛋白酶（MMP）-2和-9在所有类型腹主动脉瘤（AAA）中的表达情况：有症状的、无症状的和破裂的。采用标准免疫组织化学技术，对46例AAA患者前壁手术样本中的MMP-2和-9活性进行了研究。在大型AAA（>6 cm）中，MMP-9活性显著更高，但AAA大小与MMP-2活性之间无关联。MMP-2和MMP-9均与AAA破裂、其他并发症或症状无关。AAA中的MMP-9活性是动脉瘤大小的一个决定因素，但与临床表现无关。
